نتایج جستجو برای: Gossypol
تعداد نتایج: 670 فیلتر نتایج به سال:
Culture of bovine preimplantation embryos with gossypol, a polyphenolic pigment in cottonseed, inhibits development. Neither stage at which embryos are most sensitive to gossypol, nor the mechanism by which development is blocked is known. Our objectives were to characterize stages at which gossypol inhibits embryonic development and evaluate involvement of apoptosis in actions of gossypol. Whe...
Use of cottonseed meal in poultry diets has been avoided in large part because of fear of gossypol toxicity. Gossypol exists naturally as a mixture of 2 enantiomers that exhibit different biological activities. Two experiments were conducted to determine the relative toxicity of gossypol enantiomers on broilers. In the first experiment, 3-d-old broilers were fed a standard diet containing 0, 10...
21 Gossypol plays an important role in defense mechanism of Gossypium species and the 22 presence of gossypol also limits the utilization of cottonseeds. However, little is 23 known about the metabolism of gossypol in cotton plant. Here, Detection on the 24 dynamic tendency of gossypol content illustrated that at the germination stage, the 25 main source of gossypol was cotyledon, and at the la...
AIM To evaluate the anti-proliferative activity and mitochondrial toxicity of gossypol in endometrioma cells maintained in short-term cultures. METHODS (A) Three endometrioma cell lines from patients were treated with 25 or 50 nmol/L gossypol for up to 12 days. The effect of gossypol on the cell growth was recorded. (B) A phosphorescence oxygen analyzer was used to determine the effects of go...
Gossypol is a yellow compound produced by the cotton plant that confers resistance to pests. Gossypol exists in two enantiomeric forms, (+) and (-), and is experimentally often used as a racemate, (±)-gossypol, or complexed with acetic acid. (±)-Gossypol is found in cottonseed and cottonseed products in two forms: free gossypol, which is readily extractable with solvents, and bound gossypol. Th...
Racemic, (−)-, and (+)-gossypol were evaluated over a concentration range of 0 to 400 μg per mL for effects on several Aspergillus flavus growth parameters. In the concentration range tested, racemic gossypol did not stimulate conidial germination on water agar alone. In a germination stimulatory environment (potato dextrose medium), racemic gossypol concentrations of ≥ 200 μg per mL decreased ...
As a widely grown economic crop, cotton is the major oil and protein resource for human and livestock. But the highly toxic of gossypol in cottonseed severely restricts its effective utilization, consequently creating huge resource waste. Previous studies have shown the male germline stem cells were the most vulnerable cells in gossypol damages, but the mechanism was still unclear. We found gos...
BACKGROUND Gossypol, a natural compound present in cottonseeds, displays antiproliferative and pro-apoptotic effects against various cancer cells. The (-)-gossypol enantiomer is a more potent inhibitor of cancer cell growth. Here, the molecular mechanisms of apoptosis induced by (-)-gossypol were studied in human prostate cancer cells. MATERIALS AND METHODS After the prostate cancer cell DU-1...
Background: Cotton seed is one of the main sources of protein in animal feeds, containing gossypol, which has been shown to have toxic effects. Results reported by various studies also indicate the anti-cancer effects of gossypol on various cell types. However, its toxic effects on human and animal cells have not been fully established. This study was planned to investigate, for the first time...
Gossypol, a natural component of cottonseed meal, exists in positive (+) or negative (-) enantiomeric forms, and their levels and ratio could be altered by developing new genetic strains of cotton. Two experiments were conducted to determine the relative toxicity of the individual gossypol enantiomers in laying and broiler breeder hens. In the first experiment, 25 individually caged Hy-Line W-3...
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