Background: Breast cancer is the most common in females worldwide. Young women with breast are treated chemotherapy, which may exhibit gonadotoxicity thus inducing chemo- induced menopause a risk of deterioration their quality life.
 Method: A prospective study first its kind Algeria was carried out on 57 patients aged between 30 and 49 years that went for consultation at oncology departme...

BACKGROUND Doxorubicin (DOX), an anthracycline antibiotic, is a widely used anticancer agent. In spite of its high antitumor efficacy, the use of DOX in clinical chemotherapy is limited due to diverse toxicities, including gonadotoxicity. OBJECTIVE We investigated the protective effect of nano-zinc oxide (nZnO) as an established antioxidant on DOX-induced testicular disorders. MATERIALS AND...

CONTEXT Cytotoxic treatment may accelerate depletion of the primordial follicle pool, leading to impaired fertility and premature menopause. Assessment of ovarian damage in prepubertal girls is not currently possible, but Anti-Müllerian Hormone (AMH) is a useful marker of ovarian reserve in adults. OBJECTIVE The objective of the study was to prospectively evaluate AMH measurement in children ...

Cisplatin had shown anti-leishmanial effect both in vitro and in vivo against murine visceral leishmaniasis. The present study was designed to evaluate the effect of cisplatin on gonads of Leishmania donovani infected BALB/c mice. In drug treated animals, mild reduced spermatogenesis was observed but when antioxidants were supplemented along with cisplatin, the morphological characteristics of ...