CONTEXT The case fatality from acute poisoning with glyphosate-containing herbicides is approximately 7.7% from the available studies but these have major limitations. Large prospective studies of patients with self-poisoning from known formulations who present to primary or secondary hospitals are needed to better describe the outcome from acute poisoning with glyphosate-containing herbicides....

An analysis of selected datasets from the FDA’s drug Adverse Event Reporting System (FAERS) leads us to hypothesize that glyphosate contamination in both food and drugs is a major contributor to chronic and acute kidney failure respectively. In chronic kidney failure, glyphosate-induced pancreatitis results in the release of trypsin, causing a leaky vasculature. The albumin-bound glyphosate esc...

Introduction. Glyphosate is the first widely used herbicide against weed in genetically modified crops. Though glyphosate itself has a low toxicity, commercial products are more dangerous because of increased toxicity due to surfactants addition. There is no specific antidote for the poisoning with glyphosate-surfactant (Gly-SH). In recent times, the efficacy of intravenous lipid emulsion (ILE)...

BACKGROUND Data on the spectrum of corrosive injury to the esophagus after paraquat or glyphosate-surfactant ingestion are sparse in the literature and confined to case studies and brief reports. Therefore, this study aimed to examine the clinical features, degrees of esophageal injury, and clinical outcomes after paraquat or glyphosate herbicide ingestion, and sought to determine what associat...

In Thailand, poisoning by glyphosate (GLYP)-containing the herbicide, Roundup®, has been increasing. A high-performance liquid chromatographic (HPLC) method with UV detector has been developed for quantitating glyphosate. The serum samples (0.2 mL) were precipitated with acetonitrile (0.2 mL), and the supernatant was then injected directly into the chromatographic system using a fi xed volume l...

Glyphosate-surfactant herbicide is one of the most frequently used herbicides. Glyphosate kills plants by suppressing the shikimic metabolic pathway [1]. The mechanism of toxicity of glyphosate in mammals has been proposed to be the uncoupling of oxidative phosphorylation [2]. Surfactants are inert ingredients that are added to herbicides to precisely increase the absorption of the active compo...

Glyphosate is a commercially available herbicide which also acts as human toxin. It produces wide range of clinical manifestations ranging from throat irritation, GI tract erosion and bleeding, surfactant elated liver kidney injury, metabolic acidosis even death. We are reporting case 36 year old female who consumed around 400ml the pesticide presented to our tertiary care hospitals after 12 ho...