نتایج جستجو برای: Glycoconjugate

تعداد نتایج: 755  

2018
Zhongrui Ma Huajie Zhang Peng George Wang Xian-Wei Liu Min Chen

Glycoconjugate vaccine is composed of polysaccharides (PSs) covalently linked with carrier protein. Glycosylation site selection, as a significant factor leading to heterogeneities of glycoconjugate structure, draws more and more attentions for its impact on the immunogenicity of glycoconjugate vaccine. To elucidate the relationship between glycosylation connectivity and immunogenicity of glyco...

2013
Jon Cuccui Rebecca M. Thomas Madeleine G. Moule Riccardo V. D'Elia Thomas R. Laws Dominic C. Mills Diane Williamson Timothy P. Atkins Joann L. Prior Brendan W. Wren

Glycoconjugate-based vaccines have proved to be effective at producing long-lasting protection against numerous pathogens. Here, we describe the application of bacterial protein glycan coupling technology (PGCT) to generate a novel recombinant glycoconjugate vaccine. We demonstrate the conjugation of the Francisella tularensis O-antigen to the Pseudomonas aeruginosa carrier protein exotoxin A u...

Journal: :Mediators of Inflammation 1998
H Sossé-Alaoui C Labat I Gorenne V Thomas de Montpreville J Bara C Brink

The aim of this study was to examine glycoconjugate secretion in human airways with and without an epithelium. Glycoconjugate release in supernatants derived from human airways in vitro was determined using an ELISA assay with an anti-human mucin monoclonal antibody (MAb 3D3). This monoclonal antibody reacted strongly with Le(b) antigen but also recognized in vitro Le(a) and Le(y) determinants....

Journal: :Hong Kong medical journal = Xianggang yi xue za zhi 2012
S Y Yik M S Yu Y S Ho C S W Lai Y T Cheung K F So R C C Chang

1. Minocycline, memantine,and glycoconjugate were assessed for their ability to protect cultured primary cortical neurons against double-stranded RNA-induced neurotoxicity. 2. Minocycline but not memantine or glycoconjugate protected cultured cells and warrants further investigation.

Journal: :Journal of experimental botany 2000
J A Fernández J Escribano A Piqueras J Medina

A glycoconjugate has been characterized from saffron corms (Crocus sativus L.) that inhibits the growth of roots of Nicotiana tabacum and Arabidopsis thaliana, at concentrations ranging from 1-100 micrograms m-3. Roots of seedlings grown in the presence 0.1 microgram m-3 glycoconjugate showed bulging of epidermal cells, whereas at 10 micrograms m-3, roots were completely devoid of hairs. At 100...

Journal: :Biochemical Society transactions 2011
Napoleon Waszkiewicz Sławomir Dariusz Szajda Alina Kępka Agata Szulc Krzysztof Zwierz

Up to 30% of all hospital admissions and health-care costs may be attributable to alcohol abuse. Ethanol, its oxidative metabolites, acetaldehyde and ROS (reactive oxygen species), non-oxidative metabolites of alcohol [e.g. FAEEs (fatty acid ethyl esters)] and the ethanol-water competition mechanism are all involved in the deregulation of glycoconjugate (glycoprotein, glycolipid and proteoglyca...

Journal: :FEMS immunology and medical microbiology 1994
O Brandonisio M A Panaro R Marzio A Marangi S M Faliero E Jirillo

Lipophosphoglycan (LPG), a surface glycoconjugate of Leishmania promastigotes, has been reported as playing an active role in protecting the parasite within phagolysosomes, by an impairment of monocyte oxidative responses. In this study the effect of LPG on the oxidative burst of human peripheral monocytes, eosinophils and neutrophils was evaluated. Our results demonstrated that either superoxi...

2017
Marit Lippestad Robin R. Hodges Tor P. Utheim Charles N. Serhan Darlene A. Dartt

Purpose Goblet cells in the conjunctiva secrete mucin into the tear film protecting the ocular surface. The proresolution mediator resolvin D1 (RvD1) regulates mucin secretion to maintain homeostasis during physiological conditions and in addition, actively terminates inflammation. We determined the signaling mechanisms used by RvD1 in cultured rat conjunctival goblet cells to increase intracel...

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