we have investigated the preventive effects of oral administration of isolated e.coli ghttam'tc acid decarboxylase (gad) in animal models. based on our results, the blood glucose levels were reduced by oral administration of gad to rats 14 days before intraperitoneal injections of streptozocin (40 mg/kg on five consecutive days). on the other hand, oral administration of gad to rats before stre...

background: autoimmune type 1 diabetes mellitus is caused by t-cell mediated immune destruction of the insulin-producing β-cell in pancreatic islets of langerhans. specificity of the auto-antibodies and of the auto-reactive t-cells has been investigated, in which several auto-antigens were proposed. objective: to determine whether glutamic acid decarboxylase (gad) feeding would induce oral tole...

the diabetes is an autoimmune disease, in which the role of autoantibodies is of a specific importance. the appearance of these autoantibodies can be the first symptom in the serum of type i diabetic patients, which may appear ten years before onset of the disease. the most important autoantibodies include glutamic acid decarboxylase autoantibodies (gad65-ab). this can be used as a good tool fo...

Background: a metabolic condition characterized by failure in the metabolism of proteins, lipids, and carbohydrates that is brought on problems with insulin production. When multiple autoantibodies, such as those against glutamic acid decarboxylase, are present different antigens, type 1 diabetes present. Objective: To estimate Glutamic Acid Decarboxylase Autoantibodies assessment HbA1c DM. Met...

antibodies directed against the enzyme glutamic acid decarboxylase (gad) are believed to be the main cause of destruction of pancreatic islet cells in type i (insulin dependent) diabetes mellitus. the enzyme was found both in the brain and pancreatic beta cells. although similarities in identity of gad in human and rat brain have been demonstrated, little is known about the interaction between ...

A 6-year-old boy presented with epilepsia partialis continua 6 months after diagnosis of type 1 diabetes. Anti-glutamic acid decarboxylase 65 antibodies were found in his serum and cerebrospinal fluid. Anti-epileptic agents did not improve his seizures. High-dose steroids, plasmapheresis, and intravenous immunoglobulin resulted in decreased anti-glutamic acid decarboxylase 65 antibody levels an...

Vender, Joyce (Indiana University, Bloomington), Kunthala Jayaraman, and H. V. Rickenberg. Metabolism of glutamic acid in a mutant of Escherichia coli. J. Bacteriol. 90:1304-1307. 1965.-A mutant strain of Escherichia coli W1485 was selected for its ability to utilize glutamic acid as the sole source of carbon. Growth of the mutant on glutamic acid led to the repression of glutamic acid dehydrog...