نتایج جستجو برای: Genotoxic
تعداد نتایج: 7494 فیلتر نتایج به سال:
objective: micronuclei are induced in cells by a variety of substances, like uv radiation, infrared rays, x-radiations, and chemicals. among them tobacco- specific nitrosamines have been reported to be potent mutagenic agents which are thought to be responsible for the induction of chromosomal aberrations resulting in production of micronuclei. the main aim of our study is to compare mn frequen...
Background and Objective: Hospital wastes with the content of infectious, pathologic, sharp, pharmaceupitical and genotoxic materials are classified as hazardous wastes. Of which, genotoxic residues wirh mutagenic and teratogenic effects are of most great concern on human health. Genetic wastes are referred to as cytotoxic, chemical, and radioactive drugs used to treat cancer or treat transplan...
The aim of the present study was to evaluate Vitamin C (VC) as a potent natural antioxidant to mitigate the genotoxic effects of Arsenic trioxide and sodium fluoride in Swiss albino mice in vivo. The study was divided into eight groups consisting of control treated with normal saline (Group I), Group II, III, IV, V, VI, VII and the VC group with only Vitamin C (500 mg/kgbw). Arsenic trioxide (4...
background helicobacter pylori (h. pylori) is recognized as the causative agent of peptic and duodenal ulcers, gastric adenocarcinoma, and low-grade mucosa-associated lymphoid tissue (malt) lymphoma . in the present study, we investigate the genotoxic damage of lysates of h. pylori in human b lymphocytes. materials and methodsâ human b lymphocytes were treated with 0, 10, 20, and 30 âµg/ l of ...
the medicinal plants have been used since ancient times and are still utilized by the majority of the population. hence, it is essential to investigate the cytotoxic and genotoxic effects of these plants. the aim of this study was to evaluate the toxic effects of fennel seeds decoctions, traditionally used in iran as an herbal remedy. the cytotoxicity was tested in vitro using allium cepa l. r...
Objective: Irinotecan is a botanical derivative and an anti-cancer drug with cytotoxic and genotoxic effects. The present study evaluated the effect of Lactobacillus plantarum A7 on the genotoxic activity of irinotecan in a hepatocellular carcinoma cell line (HepG2) by comet assay. Materials and Methods: HepG2 were incubated with irinotecan (100 µM), heat-killed cells (0.025 µg/ml) + irinotecan...
Introduction: Tetracyclic antidepressants-mirtazapin is one of antidepressants drug that exhibits both noradrenergic and serotonergic activity. It is commonly used to treat major depressive disorder. The genotoxic effect of mirtazapine has not been examined previously. The purpose of this study was to investigate the genotoxic and cytotoxic effects of mirtazapine on human peripheral blood lymph...
Based on the process of carcinogenesis, carcinogens are classified as either genotoxic or non-genotoxic. In contrast to non-genotoxic carcinogens, many genotoxic carcinogens have been reported to cause tumor in carcinogenic bioassays in animals. Thus evaluating the genotoxicity potential of chemicals is important to discriminate genotoxic from non-genotoxic carcinogens for health care and pharm...
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