inflammatory bowel disease, coronary artery disease, cerebrovascular disease, hypertension, diabetes, tumours, are exam­ples of chronic degenerative diseases that have a high prevalence in developed nations. these chronic-non-communicable dis­eases have multifactorial aetiologies that considered to be caused by the interaction of environmental risk factors with multi­ple predisposing genes. gen...

autistic disorders (ads) are neuro-developmental disorders in the category of pervasive developmental disorders chiefly described by three main deficits: 1) deviant communication, 2) impaired reciprocal social interaction, and 3) limited, repetitive and stereotypic patterns of behaviors or interests 1. the world-wide prevalence of ads is estimated to be 62/10,000 1. although various treatment r...

background multiple sclerosis (ms) is an autoimmune disease that affects the central nervous system (cns). ms is one of the most common cause of neurological impairment at a young age with a complex etiology. the forkhead/winged helix (foxp3) gene encodes a transcription factor that plays an important role in the working and progress of regulatory t cells. loss of the foxp3 function impairs the...

myocardial infarction (mi) and its major determinant, coronary artery disease (cad), are complex diseases arising from the interaction between several genetic and environmental factors. until recently, the genetic basis of these diseases was poorly understood. genome-wide genetic association studies have afforded a comprehensive insight into the association between genetic variants and diseases...