Production and characterization of soft cross-linked gelatin sponge by using glutaraldehyde for blood hemostasis application, is the goal of this study. Biodegradable hydrogels were prepared through crosslinking of gelatin with glutaraldehyde followed by freeze drying. The effects of gelatin concentration, amount of crosslink agent and freeze drying temperature on mechanical properties and...

production and characterization of soft cross-linked gelatin sponge by using glutaraldehyde for blood hemostasis application, is the goal of this study. biodegradable hydrogels were prepared through crosslinking of gelatin with glutaraldehyde followed by freeze drying. the effects of gelatin concentration, amount of crosslink agent and freeze drying temperature on mechanical properties and elas...

91 Biodegradable haemostats [Absorbable gelatin sponges] and Hydrogels are a part of modern wound management systems. Development of absorbable gelatin sponges, drug loaded sponges, hydrogels and drug loaded hydrogels for advanced wound management was investigated in this research project. The developed formulations were evaluated to determine their potential for advanced wound management as de...

The application of freeze-dried gelatin sponges as alternative bone grafting substitutes has many advantages, including the ability to swell, high porosity, tailorable degradation, and versatility to incorporate multiple components such as growth factors and nanofillers. The purpose of this study was to mineralize (M) and further characterize 1-Ethyl-3-[3-dimethylaminopropyl]carbodiimide hydroc...

Microbial transglutaminase (mTG) was used as a crosslinking agent in the preparation of gelatin sponges. The physical properties of the materials were evaluated by measuring their material porosity, water absorption, and elastic modulus. The stability of the sponges were assessed via hydrolysis and enzymolysis. To study the material degradation in vivo, subcutaneous implantations of sponges wer...

In vivo adipose tissue regeneration by preadipocytes was evaluated by combining them with collagen sponges with different biodegradabilities and gelatin microspheres incorporating basic fibroblast growth factor (bFGF) for the controlled release. The collagen sponge biodegradability was regulated from 1-4 weeks by changing the cross-linking conditions in collagen sponge preparation. The time pro...

Nanofiber Sponges In article number 2100918, Jinglei Wu, Xiumei Mo, and co-workers develop a novel conjugate electrospinning strategy to prepare 3D nanofiber sponge with low density, high surface area, compressibility. This method can be widely used in the preparation of various polymer sponges. The obtained gelatin holds great potential as an absorbable hemostatic agent for rapid hemostasis.

Chen, J C; Tien, Y C; Ko, C L; Shih, C J; Wang, J C; Hung, C C; +Chen, W C Department of Orthopaedics, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan +School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan Department of Fragrance and Cosmetics Science, Kaohsiung Medical University, Kaohsiung 807, Taiwan Division of Prosthodontics, Depa...

Cryptococcosis, an increasingly important opportunistic infection caused by the encapsulated yeast-like organism Cryptococcus neoformans, is limited by an anticryptococcal cell-mediated immune (CMI) response. Gaining a thorough understanding of the complex anticryptococcal CMI response is essential for developing means of controlling infections with C. neoformans. The murine cryptococcosis mode...

Fracture healing involves the coordinated actions of multiple cytokines. Bone morphogenetic protein 9 (BMP9) is an important factor in bone formation. The present study aimed to investigate the osteogenic potential of bone marrow stem cells (BMSCs) in response to adenoviral (Ad)BMP9, and the early fracture repair properties of AdBMP9 in surgically‑created fractures in osteoporotic rats. Alkalin...