نتایج جستجو برای: Geant4-DNA

تعداد نتایج: 508519  

Journal: :Computer Physics Communications 2015
E. Delage Q. T. Pham Mathieu Karamitros Henri Payno V. Stepan Sébastien Incerti Lydia Maigne Yann Perrot

This paper describes PDB4DNA, a new Geant4 user application, based on an independent, crossplatform, free and open source C++ library, so-called PDBlib, which enables use of atomic level description of DNA molecule in Geant4 Monte Carlo particle transport simulations. For the evaluation 15 of direct damage induced on the DNA molecule by ionizing particles, the application makes use of an algori...

Journal: :Physica Medica 2021

This paper demonstrates the impact of pre-chemical stage, especially dissociation scheme and associated probabilities, on water radiolysis simulation using Geant4-DNA Monte Carlo track structure toolkit. The models parameters provided by TRACs have been collected implemented into Geant4-DNA. In order to evaluate their influence simulation, radiochemical yields (G-values) are evaluated as a func...

Journal: :iranian journal of nuclear medicine 2016
mohammad ali tajik-mansoury hossein rajabi hossein mozdarani

introduction: spatial dose distribution around the radionuclides sources is required for optimized treatment planning in radioimmunotherapy. at present, the main source of data for cellular dosimetry is the s-values provided by mird. however, the mird s-values have been calculated based on analytical formula in which no electrons straggling is taken to account. in this study, we used geant4-dna...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تحصیلات تکمیلی صنعتی کرمان - پژوهشکده برق و کامپیوتر 1383

در این مطالعه تعداد شکستهای تک رشتهای (ssb) و شکستهای دو رشتهای(dsb) dna و همینطور آسیبهای القا شده به بازها (bd) به علت اثرات مستقیم پرتوهای فرودی پروتون و ذرات ثانویه تولیدی آن در دو محیط همگن و ناهمگن به وسیله ابزارشبیهسازی مونت کارلو geant4 محاسبه شدهاند. بدین منظور دو هندسه متفاوت از یک رشته که شامل چهار dna و یک جفت باز از فرم b-dna شبیه سازی شده است

2013
M A Bernal D Sikansi F Cavalcante S Incerti C Champion V Ivanchenko Z Francis M Karamitros

We have recently developed an atomistic model of the B-DNA configuration, up to the 30-nm chromatin fiber. This model is intended to be used in Monte Carlo simulations of the DNA-radiation interaction, specifically in conjunction with the Geant4-DNA extension of the Geant4 Monte Carlo toolkit. In this work, 11449 parallel chromatin fibers have been arranged within a cube mimicking a cell nucleu...

2016
Elliott Leonard Jacob Leonard Susan Halbig

Typically water is used as an analog material for Deoxyribonucleic Acid (DNA) in Monte Carlo simulations of biological radiation interactions. Prior to this work, it was unclear whether water is an appropriate stand-in for DNA when simulating direct radiation damage on the nano scale. The increased interest in targeted tumor therapy using Auger electrons has requires an understand of the radiob...

Journal: :Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2014
C Champion S Incerti Y Perrot R Delorme M C Bordage M Bardiès B Mascialino H N Tran V Ivanchenko M Bernal Z Francis J-E Groetz M Fromm L Campos

Modeling the radio-induced effects in biological medium still requires accurate physics models to describe the interactions induced by all the charged particles present in the irradiated medium in detail. These interactions include inelastic as well as elastic processes. To check the accuracy of the very low energy models recently implemented into the GEANT4 toolkit for modeling the electron sl...

Journal: :Precision radiation oncology 2023

The scientific community shows a great interest in the study of DNA damage induction, repair and biological effects on cells cellular systems after exposure to ionizing radiation. Several in-silico methods have been proposed so far these mechanisms using Monte Carlo simulations. This outlines Geant4-DNA example application, named "molecularDNA", publicly released 11.1 version Geant4 (December 2...

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