نتایج جستجو برای: Gastro-toxicity

تعداد نتایج: 125560  

Journal: :avicenna journal of phytomedicine 0
fatima nnawodu ishaq department of pharmacology and therapeutics. faculty of pharmaceutical sciences, ahmadu bello university zaria-nigeria. abdulkadir umar zezi department of pharmacology and therapeutics, ahmadu bello university, p m b 1045, zaria-nigeria temidayo olutoyin olurishe department of pharmacology and therapeutics, ahmadu bello university, p m b 1045, zaria-nigeria

objective:the purpose of this study was to investigate the effects of piroxicam co-administration with ethanolic stem-bark extract of khaya senegalensis on biomarkers of oxidative stress and gastro-toxicity in wistar rats. materials and methods: thirty healthy male and female albino wistar rats (190-220 g) were grouped into six (n = 5) with designated treatments including: normal saline, piroxi...

Abdulkadir Umar Zezi Fatima Nnawodu Ishaq, Temidayo Olutoyin Olurishe

Objective:The purpose of this study was to investigate the effects of piroxicam co-administration with ethanolic stem-bark extract of Khaya senegalensis on biomarkers of oxidative stress and gastro-toxicity in Wistar rats. Materials and Methods: Thirty healthy male and female Albino Wistar rats (190-220 g) were grouped into six (n = 5) with designated treatments including: Normal saline, piroxi...

2014
Andrea Guttilla Roberto Bortolus Gianluca Giannarini Pirus Ghadjar Fabio Zattoni Michele Gnech Vito Palumbo Francesca Valent Antonio Garbeglio Filiberto Zattoni

BACKGROUND The optimal management of high-risk prostate cancer remains uncertain. In this study we assessed the safety and efficacy of a novel multimodal treatment paradigm for high-risk prostate cancer. METHODS This was a prospective phase II trial including 35 patients with newly diagnosed high-risk localized or locally advanced prostate cancer treated with high-dose intensity-modulated rad...

2017
Marina Borro Andrea Botticelli Federica Mazzuca Elisa Concetta Onesti Giovanna Gentile Adriana Romiti Bruna Cerbelli Eva Mazzotti Luca Marchetti Luana Lionetto Maurizio Simmaco Paolo Marchetti

BACKGROUND 5-fluorouracil (5-FU) based chemotherapy is the most common first line regimen used in gastric and gastroesophageal junction cancer, but development of severe toxicity is a main concern in the treatment. The present study is aimed to evaluate a novel pre-treatment assay, known as the 5-FU degradation rate (5-FUDR), as a predictive factor for 5-FU toxicity. METHODS Pre-treatment 5-F...

Journal: :Annals of the rheumatic diseases 1964
J S PERCY P STEPHENSON M THOMPSON

Indomethacin is an indole-3-acetic acid derivative (Fig. 1), which has been shown by animal experiments to possess powerful anti-inflammatory and anti-pyretic properties without evidence of toxicity other than causing diarrhoea and gastro-intestinal irritation when given in excessive dosage (Hodgkinson, 1963). Preliminary reports of its action in arthritic patients have been given at the Americ...

Journal: :Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) 2001

2014
Fatima Nnawodu Ishaq Abdulkadir Umar Zezi Temidayo Olutoyin Olurishe

OBJECTIVE The purpose of this study was to investigate the effects of piroxicam co-administration with ethanolic stem-bark extract of Khaya senegalensis on biomarkers of oxidative stress and gastro-toxicity in Wistar rats. MATERIALS AND METHODS Thirty healthy male and female Albino Wistar rats (190-220 g) were grouped into six (n = 5) with designated treatments including: Normal saline, pirox...

2016
Christopher Coyle Fay H. Cafferty Samuel Rowley Mairead MacKenzie Lindy Berkman Sudeep Gupta C S Pramesh Duncan Gilbert Howard Kynaston David Cameron Richard H. Wilson Alistair Ring Ruth E. Langley

BACKGROUND There is a considerable body of pre-clinical, epidemiological and randomised data to support the hypothesis that aspirin has the potential to be an effective adjuvant cancer therapy. METHODS Add-Aspirin is a phase III, multi-centre, double-blind, placebo-controlled randomised trial with four parallel cohorts. Patients who have undergone potentially curative treatment for breast (n=...

2015

This study is aimed at evaluating the phytochemical constituents and the antidiarrheal activities of the acetone extract of Acacia sieberiana stem bark. The phytochemical screening was carried out to identify the active constituents present in the acetone extract, and the acute toxicity test was also carried to determine the safety limit of the extract. Gastro intestinal motility and castor oil...

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