نتایج جستجو برای: Gastro-toxicity
تعداد نتایج: 125560 فیلتر نتایج به سال:
objective:the purpose of this study was to investigate the effects of piroxicam co-administration with ethanolic stem-bark extract of khaya senegalensis on biomarkers of oxidative stress and gastro-toxicity in wistar rats. materials and methods: thirty healthy male and female albino wistar rats (190-220 g) were grouped into six (n = 5) with designated treatments including: normal saline, piroxi...
Objective:The purpose of this study was to investigate the effects of piroxicam co-administration with ethanolic stem-bark extract of Khaya senegalensis on biomarkers of oxidative stress and gastro-toxicity in Wistar rats. Materials and Methods: Thirty healthy male and female Albino Wistar rats (190-220 g) were grouped into six (n = 5) with designated treatments including: Normal saline, piroxi...
BACKGROUND The optimal management of high-risk prostate cancer remains uncertain. In this study we assessed the safety and efficacy of a novel multimodal treatment paradigm for high-risk prostate cancer. METHODS This was a prospective phase II trial including 35 patients with newly diagnosed high-risk localized or locally advanced prostate cancer treated with high-dose intensity-modulated rad...
BACKGROUND 5-fluorouracil (5-FU) based chemotherapy is the most common first line regimen used in gastric and gastroesophageal junction cancer, but development of severe toxicity is a main concern in the treatment. The present study is aimed to evaluate a novel pre-treatment assay, known as the 5-FU degradation rate (5-FUDR), as a predictive factor for 5-FU toxicity. METHODS Pre-treatment 5-F...
Indomethacin is an indole-3-acetic acid derivative (Fig. 1), which has been shown by animal experiments to possess powerful anti-inflammatory and anti-pyretic properties without evidence of toxicity other than causing diarrhoea and gastro-intestinal irritation when given in excessive dosage (Hodgkinson, 1963). Preliminary reports of its action in arthritic patients have been given at the Americ...
OBJECTIVE The purpose of this study was to investigate the effects of piroxicam co-administration with ethanolic stem-bark extract of Khaya senegalensis on biomarkers of oxidative stress and gastro-toxicity in Wistar rats. MATERIALS AND METHODS Thirty healthy male and female Albino Wistar rats (190-220 g) were grouped into six (n = 5) with designated treatments including: Normal saline, pirox...
BACKGROUND There is a considerable body of pre-clinical, epidemiological and randomised data to support the hypothesis that aspirin has the potential to be an effective adjuvant cancer therapy. METHODS Add-Aspirin is a phase III, multi-centre, double-blind, placebo-controlled randomised trial with four parallel cohorts. Patients who have undergone potentially curative treatment for breast (n=...
This study is aimed at evaluating the phytochemical constituents and the antidiarrheal activities of the acetone extract of Acacia sieberiana stem bark. The phytochemical screening was carried out to identify the active constituents present in the acetone extract, and the acute toxicity test was also carried to determine the safety limit of the extract. Gastro intestinal motility and castor oil...
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