Background: Gastric cancer (GC) is considered as one of the most common types of cancer worldwide with poor prognosis and generally limited treatment options. Recent studies have indicated that HER2, MDM2, MYC, MET, and TP53 play an important role in the development of gastric cancer. Therefore, the aim of this study was to evaluate the incidence of amplification/deletion of these genes in pati...

Gastric cancer is one of the most common cancers in the world. Late diagnosis is the main cause of the high rate of treatment failure and death among patients with gastric cancer; therefore identifying the molecular basis of cancer initiation and metastasis is so critical for developing efficient methods for early diagnosis and therapy. long non-coding RNAs (lncRNAs) are the largest group of no...

BACKGROUND/AIMS Controversy exists regarding the characteristics of Helicobacter pylori infection-negative gastric cancer (HPIN-GC). The aim of this study was to evaluate clinicopathologic features of HPIN-GC compared to H. pylori infection-positive gastric cancer (HPIP-GC) using a comprehensive analysis that included genetic and environmental factors. METHODS H. pylori infection status of 70...

normal 0 false false false en-us x-none fa microsoftinternetexplorer4 aim : this study aimed to determine the association between pd-1.5c/t (rs2227981, +7785) and the risk of gastric cancer (gc) in an iranian population. background : gastric cancer is the fourth most common cancer in the world. the programmed death 1 (pd-1) is a member of the cd28 super family. pd-1 is a negative regulator of t...

BACKGROUND Bone marrow mesenchymal stem cells (BM-MSCs) have been identified to be closely associated with tumor growth and progression. However, the roles of tumor-resident MSCs in cancer have not been thoroughly clarified. This study was to investigate the regulating effect of gastric cancer-derived MSCs (GC-MSCs) on gastric cancer and elucidate the underlying mechanism. METHODS GC-MSCs wer...

helicobacter pylori was the main cause of gastric cancer (gc) in all over the world that results in intestinal- and diffuse-type carcinoma. infection by this bacterium remains chronic for a long time. in vitro studies have highlighted the role of stem cells in gc. h. pylori infection results in tissue injury and the adult/tissue stem cells subsequently start to replace the dead cells. the genet...

background: gastric cancer (gc) is the fifth common malignant disease and the third leading cause of cancer-related mortality in the world. ardabil, a northwestern province of iran, includes the highest rate of gc within the country. helicobacter pylori (h. pylori) vaca gene plays a major role in generating and maintaining the gastric inflammatory response , which alters the enteric nervous sys...

Gastric cancer (GC) is the fifth most commonly diagnosed and third leading cause of cancer-related death in world. Microbiota believed to be associated with GC. Growing evidences showed Helicobacter pylori played a key role GC development. However, little was known about microbiota gastric juices tissues patients, thus it difficult understand other potential microbial causation for Here, we col...

background: gastric cancer (gc) is one of the most commonly diagnosed malignancies. genetic variation in genes encoding cytokines and their receptors, determine the intensity of the inflammatory response, which may contribute to individual differences in the outcome and severity of the disease. interleukin-10 (il-10) is a multifunctional cytokine with both immunosuppressive and antiangiogenic f...