The utilization of SCFs for the processing of several products has attracted considerable interest in recent years as an emerging “green” technology. Particle formation using SCFs can be carried out according to several different techniques, including antisolvent techniques such as the gas-antisolvent (GAS) process. The potential advantages of the GAS crystallization process lies in the possibi...

Due to its low bioavailability and slow dissolution rate, the micronized spiramycin powder was thus prepared by the homogenate-antisolvent precipitation (HAP) process. The optimum micronization conditions of the HAP process were found to be as follows: precipitation temperature of 4.6 ◦C, precipitation time of 10 min, spiramycin concentration of 20 mg/mL, dripping speed of the added solvent int...

Differences in physical and chemical properties between polymorphic compounds (e.g. solubility, dissolution rate, chemical reactivity, resistance to degradation, bioavailability) are highly significant for the pharmaceutical industry, which requires effective methods to control polymorphism of organic crystals [1, 2]. In particular, to improve the functionality such as solubility or bioavailabi...

Objective(S): In this work, paclitaxel (PX), a promising anticancer drug, was loaded in the basil seed mucilage (BSM) aerogels by implementation of supercritical carbon dioxide (SC-CO2) technology. Then, the effects of operating conditions were studied on the PX mean particle size (MPS), particle size distribution (PSD) and drug loading efficiency (DLE). <stron...

In this work the volume expansion for the binary systems of ethanol and toluene, as industrial organic solvents, in the presence of nearcritical and supercritical carbon <span style="font-size: 10pt; c...