UV exposure is associated with oxidative stress and is the primary factor in skin photoaging. UV-induced reactive oxygen species (ROS) cause the up-regulation of metalloproteinase (MMPs) and the degradation of dermal collagen and elastic fibers. Garlic and its components have been reported to exert antioxidative effects. The present study investigated the protective effect of garlic on UV-induc...

BACKGROUND In ancient times, plants were recognized for their medicinal properties. Later, the arrival of synthetic drugs pushed it to the backstage. However, from being merely used for food, plants are now been widely explored for their therapeutic value. The current study explores the potential of skin and flesh extracts from a hard-necked Rocambole variety of purple garlic in preventing card...

Dithranol is a potent agent in treating psoriasis but its adverse effects on intact skin have limited its usage. There are many proposed mediators for its adverse effects including prostaglandins, histamine, platelet activating factor and free radicals. In this study we examined the effect of different agents (diazepam, terfenadine, indomethacin and garlic extract) on dithranol-induced skin dam...

Garlic (Allium sativum L. fam. Alliaceae) is one of the best-researched, best-selling herbal remedies and is also commonly used for treating various health problems. Garlic is widely known for its biological properties and plays an important role as an antioxidant. The purpose of this review is to gather and summarize all dermatologic-oriented in vitro and in-vivo experiments and clinical trial...

High garlic dose could exert adverse health properties and grape seed and skin extract (GSSE) exhibit a variety of beneficial effects, even at high dose. In the present study we evaluated the toxic effect of high garlic dose treatment on antioxidant status of the blood compartment and the protective effect of GSSE. Rats were intraperitoneally (i.p.) administered either with garlic extract (5 g/...

An inverse relationship exists between the consumption of garlic and the risk of certain cancers. The present study was aimed at investigating the effect of garlic constituent diallyl trisulfide (DATS) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cyclooxygenase-2 (COX-2) expression and tumor promotion in mouse skin and to explore the underlying molecular mechanisms. Pretreatment of mou...

In their Research Letter, Ms Stjernberg and Dr Berglund1 documented a repellent effect of garlic against an unnamed species of tick and stated that daily consumption of 1200 mg of garlic was an alternative to “other agents that might have more adverse effects.” Based on the design of their study, any conclusions concerning the relative effectiveness and safety of garlic as a tick repellent are ...

For the value-added utilization of underutilized agricultural by-products, garlic skin obtained abundantly in the food processing industry has been tested as a new source of cellulosic materials. Cellulose microfibers (CMF) and cellulose nanocrystals (CNC) were isolated from garlic skin fibers by alkali treatment and acid hydrolysis. The crude fiber, CMF, and CNC of garlic skin were characteriz...

Skin cancer is a serious concern whose incidence is increasing at an alarming rate. Allyl sulfides-i.e., sulfur metabolites in garlic oil-have been demonstrated to have anticancer activity against several cancer types, although the mechanisms underlying these effects remain enigmatic. Our previous study showed that diallyl trisulfide (DATS) is more potent than mono- and disulfides against skin ...

Aging is a process experienced by the human body where function of parts becomes reduced, for example, skin getting thinner and then wrinkles appear. Premature aging occurs due to photoanging UV radiation some bad living habits. In reducing signs on skin, antioxidants are needed protect from damage caused oxidation so that it can prevent premature aging. Antioxidants be enzymes (eg superoxide o...