one of the complications of Beta-thalasemia major is hepatobiliary disorders for example cholelithiasis(Gallstone),in this study frequency of hepatobiliary ultra sound abnormal findings in 200 patients in Kerman was investigated.among 200 patients ,11(5.5%) had gallstone.the average age of patients without  gallstone was 10.07+_4.9 years and that of patients with  gallstone was 16.1+_5 years.th...

gastrointestinal obstruction by a gallstone is an uncommon but important complication of biliary stone disease which mostly affects the elderly. the classic triad of radiological features includes pneumobilia, ectopic gallstone and evidence of intestinal obstruction. terminal ileum is the most common site of obstruction, followed by jejunum and gastric outlet. we present a case of duodenal gall...

BACKGROUND Lithogenic bile is the major cause of cholesterol gallstone, but its pathogenesis is not well understood. The hypersecretion of biliary cholesterol is believed to be an important cause of lithogenic bile. Sterol Carrier Protein 2 (SCP2) participates in cholesterol trafficking and lipid metabolism in hepatocytes and may play a key role in cholesterol gallstone formation. METHODS 21 ...

Bile lipid and bile acid compositions of twenty-five diabetic patients (eight males and seventeen females) were compared with those of twenty normal subjects and twelve non-diabetic patients with cholesterol gallstone. Diabetic patients were grouped into the untreated, insulin-treated and untreated patients with gallstone. The results are as follows. The average molar percentage of cholesterol ...

Gallstone ileus with impaction of gallstone in distal duodenum is an extremely rare complication of cholecystolithiasis. Gallstone ileus in itself accounts for less than 1% of these complications with 800 cases described so far. However, there are less than 15 cases described with the impaction of gallstone in distal duodenum. We report a case of an 84-year-old male patient in whom gallstone im...

Aim It was aimed to assess the association of four polymorphisms and relative haplotypes in the ATP binding cassettes and cholecystokinin A receptor (rs6720173, rs11887534, rs4148217, rs1800857) with the risk of gallstone. Background Gallstone is a multifactorial disease. Besides high penetrance genes, low or moderate penetrance polymorphisms may increase susceptibility to gallstone. Method...

Hepatic cholesterol metabolism was examined in 27 Swedish patients with cholesterol gallstone disease and in 13 patients free of gallstones operated for roentgenographically suspect polyps in the gallbladder. All 40 patients underwent cholecystectomy, and a liver biopsy and gallbladder bile were obtained at surgery. The cholesterol saturation of gallbladder bile was significantly higher in pati...