Although GPC has long been recognized as a degradation product of phosphatidylcholine, only recently is there wide appreciation of its role as a compatible and counteracting osmolyte that protects cells from osmotic stress. GPC is osmotically regulated in renal cells. Its level varies directly with extracellular osmolality. Cells in the kidney medulla in vivo and in renal epithelial cell cultur...

Series of benzoolysis experiments with 1,2-dipalmitoyl glycerophosphocholine (GPC), 1-palmitoyl-2-lyso GPC, and 1-O-hexadecenyl-2-oleoyl GPC, as well as a few experiments with 1-oleoyl-2-acetyl GPC and 1-O-hexadecyl-2-acetyl GPC are reported. The results are used to present a consistent picture of the various dephosphorylation and benzoylation reactions occurring in molten benzoic anhydride.

In this paper we present an adaptive multi-element generalized polynomial chaos (ME-gPC) method, which can achieve hp-convergence in random space. ME-gPC is based on the decomposition of random space and generalized polynomial chaos (gPC). Using proper numerical schemes to maintain the local orthogonality on-the-fly, we perform gPC locally and adaptively. The key idea is to combine the polynomi...

Three binary protein-protein interactions, glycophorin C (GPC)-4.1R, GPC-p55, and p55-4.1R, constitute the GPC-4.1R-p55 ternary complex in the erythrocyte membrane. Little is known regarding the molecular basis for the interaction of 4.1R with either GPC or p55 and regarding the role of 4.1R in regulating the various protein-protein interactions that constitute the GPC-4.1R-p55 ternary complex....

Two rat monoclonal antibodies (BRAC 1 and BRAC 11) have been produced. BRAC 1 recognizes an epitope common to the human erythrocyte membrane glycoproteins glycophorin C (GPC) and glycophorin D (GPD). BRAC 11 is specific for GPC. Fab fragments of these antibodies and BRIC 10, a murine monoclonal anti-GPC, were radioiodinated and used in quantitative binding assays to measure the number of GPC an...

Introduction: Phosphocholine (PC) and total choline-containing compounds (tCho = glycerophosphocholine (GPC) + PC + free choline (Cho)) are elevated in human breast cancers, as demonstrated by numerous H magnetic resonance (MR) spectroscopy (MRS) studies [1, 2]. A switch from high GPC and low PC to low GPC and high PC characterizes the choline metabolite profile of breast [3] and ovarian [4] ca...

Based on the coefficient mapping of eigenpolynomial from plant to GPC closed-loop system in the IMC structure, the solvability of the optimal control law of GPC and some properties of GPC in relationship with tuning parameters are discussed. Theorems on GPC resulting in deadbeat control are given by properly ehtx~ng the design parameters. Furthermore, new result about reducing GPC closed-loop s...