نتایج جستجو برای: GK model

تعداد نتایج: 2106445  

پایان نامه :دانشگاه آزاد اسلامی - دانشگاه آزاد اسلامی واحد علوم دارویی - دانشکده داروسازی 1393

هدف از این پروژه تعیین میزان سرب و کادمیوم موجود در برندهای مختلف سیگار موجود در بازار ایران از طریق اندازه گیری این فلزات در فیلترسیگار می باشد. لذا برای این منظور ??برند داخلی و خارجی از مراکز خرید تهران خریداری شد. تکنیک به کار گرفته شده جهت آماده سازی نمونه ها، هضم اسیدی بود که توسط دستگاه اسپکتروسکوپ جذب اتمی شعله دو فلز سرب و کادمیوم مورد اندازه گیری کمّی قرار گرفت. سرب و کادمیوم در همه بر...

Journal: :Human molecular genetics 2000
Y Ai Z Zheng A O'Brien-Jenkins D J Bernard T Wynshaw-Boris C Ning R Reynolds S Segal K Huang D Stambolian

Galactokinase (GK; EC 2.7.1.6) is the first enzyme in the metabolism of galactose. In humans, GK deficiency results in congenital cataracts due to an accumulation of galactitol within the lens. In an attempt to make a galactosemic animal model, we cloned the mouse GK gene (Glk1) and disrupted it by gene targeting. As expected, galactose was very poorly metabolized in GK-deficient mice. In addit...

Journal: :American journal of physiology. Endocrinology and metabolism 2008
Jamileh Movassat Danièle Bailbé Cécile Lubrano-Berthelier Françoise Picarel-Blanchot Eric Bertin Jacques Mourot Bernard Portha

The adult Goto-Kakizaki (GK) rat is characterized by impaired glucose-induced insulin secretion in vivo and in vitro, decreased beta-cell mass, decreased insulin sensitivity in the liver, and moderate insulin resistance in muscles and adipose tissue. GK rats do not exhibit basal hyperglycemia during the first 3 wk after birth and therefore could be considered prediabetic during this period. Our...

Journal: :Journal of chemical theory and computation 2007
Michael J Schnieders Jay W Ponder

The generalized Born (GB) model of continuum electrostatics is an analytic approximation to the Poisson equation useful for predicting the electrostatic component of the solvation free energy for solutes ranging in size from small organic molecules to large macromolecular complexes. This work presents a new continuum electrostatics model based on Kirkwood's analytic result for the electrostatic...

2016
Kun Cai Jing Luo Yiru Ling Jing Wan Qing-hua Qin

Graphene is an active element used in the design of nano-electro-mechanical systems (NEMS) owing to its excellent in-plane physical properties on mechanical, electric and thermal aspects. Considering a component requiring negative Poisson's ratio in NEMS, a graphene kirigami (GK) containing periodic re-entrant honeycombs is a natural option. This study demonstrates that a GK with specific auxet...

2011
Anna Vidal-Alabró Alícia G. Gómez-Valadés Andrés Méndez-Lucas Jordi Llorens Ramon Bartrons Jordi Bermúdez Jose C. Perales

Recent reports point out the importance of the complex GK-GKRP in controlling glucose and lipid homeostasis. Several GK mutations affect GKRP binding, resulting in permanent activation of the enzyme. We hypothesize that hepatic overexpression of a mutated form of GK, GK(A456V), described in a patient with persistent hyperinsulinemic hypoglycemia of infancy (PHHI) and could provide a model to st...

2012
Sara A. Beddow Varman T. Samuel

The Goto-Kakizaki (GK) rat is an inbred model of type 2 diabetes (T2D); GK rats are lean but have hyperglycemia and increased gluconeogenesis. However, fasting hyperglycemia in other commonly used rodent models of T2D is associated with increased corticosterone, and thus the underlying mechanism for hyperglycemia differs significantly from T2D in humans. Information regarding corticosterone in ...

Journal: :International journal of clinical and experimental pathology 2014
Xu Sun Meizhu Zheng Maomin Song Rixing Bai Shi Cheng Ying Xing Huisheng Yuan Pilin Wang

This study is to explore the possible mechanism of ileal interposition (IT) treatment of glycemic control of the type 2 diabetes mellitus (T2DM) by establishing an IT animal model. Twelve T2DM rats (GK rats) of 8-week old were divided into GK IT surgery group (GK-IT) and GK sham group (GK-Sham). Six Wistar rats were used as the non-T2DM sham group (WS-Sham). Enzyme-linked immunosorbent assay wa...

2017
Massaine Bandeira E Sousa Jaime Cuevas Evellyn Giselly de Oliveira Couto Paulino Pérez-Rodríguez Diego Jarquín Roberto Fritsche-Neto Juan Burgueño Jose Crossa

Multi-environment trials are routinely conducted in plant breeding to select candidates for the next selection cycle. In this study, we compare the prediction accuracy of four developed genomic-enabled prediction models: (1) single-environment, main genotypic effect model (SM); (2) multi-environment, main genotypic effects model (MM); (3) multi-environment, single variance G×E deviation model (...

Journal: :Acta Biochimica et Biophysica Sinica 2009

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