GoLoco ('Galpha(i/o)-Loco' interaction) motif proteins have recently been identified as novel GDIs (guanine nucleotide dissociation inhibitors) for heterotrimeric G-protein alpha subunits. G18 is a member of the mammalian GoLoco-motif gene family and was uncovered by analyses of human and mouse genomes for anonymous open-reading frames. The encoded G18 polypeptide is predicted to contain three ...

A (λKv, G)-design is a partition of the edges of λKv into subgraphs each of which is isomorphic to G. In this paper, we completely solve the case when G = G18 (G18 is notation from Bermond, Huang, Rosa and Sotteau, Ars Combin. 10 (1980), 211–254) and prove that the necessary condition λv(v− 1) ≡ 0 (mod 14) for the existence of a (λKv, G18)-design with any positive integer λ is also sufficient e...

OBJECTIVE The present study evaluates a questionnaire on ambivalence over emotional expressiveness, the AEQ-G18 [1], [2], with regard to its statistical parameters, the influence of socio-demographic variables, and its interrelationship with depression and quality of life. METHODS A representative German sample (1009 participants from East Germany and 1034 participants from West Germany) comp...

Taxol is a chemotherapeutic drug which acts by stabilizing microtubules, preventing normal mitosis and resulting in a block of the cell cycle at G2 and M. The drug is isolated from the yew, Taxus sp. l.., and is currently being evaluated in a series of Phase II and Phase III clinical trials. Taxol blocks cells in the most radiosensitive phases of the cell cycle and thus could act as a cell cycl...

Bovine tuberculosis has been an escalating animal health issue in the United Kingdom since the 1980s, even though control policies have been in place for over 60 years. The importance of the genetics of the etiological agent, Mycobacterium bovis, in the reemergence of the disease has been largely overlooked. We compared the interaction between bovine monocyte-derived macrophages (bMDM) and two ...

In situ X-ray diffraction was used to study the interactions of the PNNL G18 fuel cell sealing glasses with the oxides that form on candidate interconnect alloys and with the ebrite alloy. Experiments under 4% hydrogen and air at temperatures up to 1000 °C showed that both sealants react rapidly with alumina and chromia, but not with NiO. The crystallization of the high-CTE phase BaCrO4 was not...

This introduces the symposium on financial economics. JEL Classification Codes: G01, G02, G11, G12, G18, G21, G23, G28

Dog hemoglobin has four sulphydryl groups at positions olfl (G18) and p93 (F9), all of which are titratable with mercurials. Only two of these, however, react with non-mercurial sulphydryl reagents. Kinetic results indicate that the reacting site might be the p”” (F9). An examination of the environment of the alI1 (G18) shows that this sulphydryl must be unreactive towards non-mercurials becaus...