Twelve 1-phenyl-, 1-thiocarbamoyl- and 1-N-substituted thiocarbamoyl-3-(2-furyl)-5-phenyl/(2-furyl)-2-pyrazoline derivatives were synthesized. The chemical structures of the compounds were proved by IR, (1)H NMR, Mass spectrometric data and microanalyses. The antidepressant activities of the compounds were investigated by Porsolt's behavioural despair (forced swimming) test on albino mice. 1-N-...

An exothermic reaction, leading to 3-(2-furyl)acrylic anhydride and a little amount of furfurylideneacetone is taking place when reacting 3-(2-furyl)acrylic acid in acetic anhydride above 120°C. The 3-(5-acetyl-2-furyl)acrylic acid was formed under the afore-mentioned conditions only in the presence of H 3 P 0 4 . The 3-(2-furyl)acrylic anhydride is more stable towards HNO, at temperatures unde...

Aq4{5-Nitro-2-furyl)-2-thiazolyl]acetamide (NFTA), fed to female Swiss mice at doses of 0.05 and 0.1% of the diet, induced a high incidence of lymphocytic leukemia and a low incidence of forestomach tumors. Several other chemicals structurally related to NFTA were also fed to female Swiss mice to determine structure-activity relationships with respect to organ specificity. 7V-[4-(5-Nitro-2-fury...

Dietary administration of N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide to mice for 14 weeks followed by 16 weeks of control diet resulted in a high incidence of lymphocytic leukemia and a low incidence of forestomach squamous cell papillomas. The coadministration of p-hydroxyacetanilide at a dose of 1.0% with either 250 or 500 ppm of N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide resulted in inhi...

In the title compound, C(30)H(20)N(2)O(2), the orientation of the furyl group may induce a variety of coordination modes with this ligand. The dihedral angle between the two naphthyl rings is 79.25 (7)°. The furyl groups make dihedral angles of 62.0 (1) and 16.3 (2)° with the attached naphthyl groups. The dihedral angle between the two furyl rings is 49.3 (2)°.

Immune status and target organ histology were temporally evaluated in mice fed either carcinogenic 5-nitrofurans or their noncarcinogenic nornitro analogs. Mice were fed either the leukemogen A/-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide (NFTA) or the urinary bladder carcinogen A/-[4-(5-nitro-2-furyl)2-thiazolyl]formamide or their nornitro analogs, A/-[4-(2-furyl)2-thiazolyl]acetamide or A/-{4-...

Immune status and target organ histology were temporally evaluated in mice fed either carcinogenic 5-nitrofurans or their noncarcinogenic nornitro analogs. Mice were fed either the leukemogen A/-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide (NFTA) or the urinary bladder carcinogen A/-[4-(5-nitro-2-furyl)2-thiazolyl]formamide or their nornitro analogs, A/-[4-(2-furyl)2-thiazolyl]acetamide or A/-{4-...

2-Hydrazino-4-(5-nitro-2-furyl)thiazole , 2-(2 , 2-dimethyihy drazi no)-4-(5-nitro-2-furyl)thiazole, 2-hydrazino-4-(4-nitro phenyl)thiazole, and 2-hydrazino-4-(4-aminophenyl)thiazole were fed to female Sprague-Dawley rats, and all were found to be potent carcinogens. Each induced chiefly carcinomas of the mammary gland (32/35 , 30/3 1, 27/34, 34/35 , respec tively), as well as a lower incidence...

A photochemical route for the synthesis of some benzopyronospiropyrans from 2-furyl-3-cycloalkenyloxybenzopyrones involving H-abstraction is reported. How a methyl group on the furyl ring affects the product formation is also investigated.

  Quinolone antibacterial agents are currently used for the treatment of various bacterial infections. The nature of functional group at the 7 position of the quinolone ring system is known to have strong influence on the spectrum and extent of in vitro antibacterial activity. Accordingly, a series of N-L2- oxo-2-(2- furyl) and N-[2- oxyimino (2- furyl) ethyl] piperazinyl quinolone derivatives...