Biodegradable polymeric nanoparticles (NPs) have been intensively studied as a possible way to enhance anti-tumor efficacy while reducing side effects. ICD-85, derived from the venom of two separate species of venomous animals, has been shown to exhibit anti-cancer activity. In this report polymer based sodium alginate nanoparticles of ICD-85 was used to enhance its therapeutic effects and redu...

A considerable issue in designing catadioptric imaging systems is what shape the component mirrors should be formed. In this paper, we propose a new algorithm for a catadioptric imaging system that satisfies the desired projection using a free-form mirror. A free-form mirror expressed as an assembly of gradients is a flexible surface representation that can form various shapes including non-smo...

With the advent of sketch-based methods for shape construction, there’s a new degree of power available in the rapid creation of approximate shapes. Sketch [Zeleznik, 1996] showed how a gesture-based modeler could be used to simplify conventional CSG-like shape creation. Teddy [Igarashi, 1999] extended this to more free-form models, getting much of its power from its "inflation" operation (whic...

In this work, the matching problem between two free-form parametric surfaces, S 0 (u, v) and S 1 (u, v), has been considered in the context of a "rst stage of the metamorphosis process, which is de"ned as gradual and continuous transformation of one key shape into another. A method is presented to approximate the two reparametrization functions, r(u, v) and t(u, v), via a discrete sampled set o...

This paper presents an analytical method for planning an efficient tool-path in machining free-form surfaces on 3-axis milling machines. This new approach uses a nonconstant offset of the previous tool-path, which guarantees the cutter moving in an unmachined area of the part surface and without redundant machining. The method comprises three steps: (1) the calculation of the tool-path interval...