chemotherapy research highly prioritizes overcoming the multidrug resistance (mdr) in human tumors. liposomal formulation of fluoxetine, as a fourth generation chemosensitizer, was constructed and characterized for percent entrapment, release profile, morphology, particle size, zeta potential and stability. liposomes were prepared using different active loading techniques. the influence of diff...

There has been certain criticism raised by A. Rescigno [2,8,9,12-15] against the standard formulation of pharmacokinetics. In 2011 it has been suggested that inconsistencies in pharmacokinetics should be eliminated after deriving “pharmacokinetic parameters” from conservation laws [3]. In the following text a simple system of conservation laws for extra vascular administration of a drug is expl...

In the present study, 3 factorial design was used to investigate the combined influence of three independent variables in the preparation of Cytarabine liposomes by thin film hydration method. The process variables like rotation speed, temperature, vacuum applied and hydration time were kept constant through out the study. The formulation variables, Drug (Cytarabine) / Lipid [Phosphatidyl choli...

Background: The aim of this study was to formulate and evaluate the noble herbal moisturise gel containing Stevia extract. Methods: The cosmetic gel formulation was designed by using aqueous extract of Stevia rebaudiana leaves in varied concentrations (2.5% and 5.0%) and evaluated using physiological measurements in comparision with a control placebo gel. The initial physicochemical parameters ...

a total of 1440 arian chicks were used in this study to determine the effects of diet formulation methods on performance and blood parameters of arian chicks. eight diets were arranged in a 2×2×2 factorial design with 2 methods of energy expression (apparent (amen) and true (tmen) metabolizable energy corrected to n equilibrium), 2 methods of amino acids content of feeds (total (taaf) and diges...

in this study, the pharmacokinetic parameters of two marketed tablet formulations of ketoconazole were studied, and the relative bioavailability of the test formulation was compared with a reference formulation. a single dose (12x2) double blind randomized cross-over study of a generic formulation of ketoconazole tablet (2x200 mg), and a commercial brand, nizoral tablet (2x200 mg, janssen pharm...

background: this study investigated the effects of some important meteorological parameters and filler type compounds on phytotoxicity of captan in peach trees in the north of iran. captan is a phthalimide fungicide which has frequently been used in northern regions of iran to control certain plant diseases. this fungicide has caused intense phytotoxicity in peach trees which was first observed...

Effects of formulation parameters on the fractional release profile of diclofenac sodium from matrices having the manufacturing formulation ingredients are studied. As a content of cetyl alcohol (rate controlling agent) in the matrix increases, the fractional release decreases. The fractional release increases either by increasing sucrose content outside the granule or by decreasing sucrose...

effects of formulation parameters on the fractional release profile of diclofenac sodium from matrices having the manufacturing formulation ingredients are studied. as a content of cetyl alcohol (rate controlling agent) in the matrix increases, the fractional release decreases. the fractional release increases either by increasing sucrose content outside the granule or by decreasing sucrose con...

This paper presents a method for the analysis of arbitrary shape and composition posts in waveguide. The method segments the problem into regions that are characterized by their generalized admittance matrices. Both an analytical formulation and a boundary integral formulation based on homogeneous wave equation solutions are used in this characterization. Our method is especially fast and suita...