FOOD reactions as a cause of illness were recognized as early as the first century B.C. by Lucretius, who observed that "one man's meat is another man's poison." Over the subsequent years it has become obvious that this poison may take the form of infection, toxic reaction, pharmacologic (as in the "Chinese restaurant syndrome" due to monosodium glutamate), enzyme deficiencies (such as lactase)...

Brilliant blue is largely found in ice cream, canned processed peas, packet soups, blue raspberry flavored products, dairy products, sweets and drinks. It is also used in soaps, shampoos, mouthwash and other hygiene and cosmetics applications (Archived from Florida). This study was aimed to investigate the antimicrobial effects of Brilliant blue on Bacillus subtilis as a gram positive bacterial...

allura red (ar) is a widely used colorant in food industry, but there is debate on its potential security risk. in this study, in vitro inhibitory properties of the dye against carbonic anhydrase (ca) were evaluated. the esterase activity of purified ca decreased in the presence of ar, in a dose-dependent manner. regarding literature review and observed results, this preliminary study may provi...

The effects of sulfanilic acid, a major azo food dye metabolite, were studied in normal developing rat pups and pups treated with 6-hydroxydopamine (60HDA). Chronic daily intraperitoneal injection of sulfanilic acid during the first postnatal month elicited hyperactivity and impaired shock escape performance in vehicle pups. No differences were noted in 60HDA treated rat pups receiving sulfanil...

The food dye FD&C Blue No. 1 (Brilliant Blue FCF [BB FCF]) is structurally similar to the purinergic receptor antagonist Brilliant Blue G (BBG), which is a well-known inhibitor of the ionotropic P2X7 receptor (P2X7R). The P2X7R functionally interacts with the membrane channel protein pannexin 1 (Panx1) in inflammasome signaling. Intriguingly, ligands to the P2X7R, regardless of whether they are...

We investigated the effects of food dye consumption on locomotor activity, brain neurotransmitters, tissue vitamin B-6 levels, and hepatic cytochrome P-450 concentrations in postweanling rats. Animals were individually housed in stabilimeter-type activity cages for 4 1/2 weeks, and fed ad libitum a semipurified basal diet containing graded levels (4, 2, 1, 0.5 or 0%) of a blend of all seven Foo...