Background: Strenuous exercise and temperature outside the optimum are associated with hypothalamic dysfunction and therefore disruption of fertility in females. The aim of this study was to evaluate serum Estradiol level and follicogenesis in adult mice exposed to forced swimming in different temperature waters. Materials and Methods: Adult female mice were randomly divided into four groups as...

Background: Melatonin as the major hormone produced by the pineal gland has a significant role in mammalian reproduction. In this study the efficacy of melatonin coadministration with nicotine on mouse follicogenesis was investigated. Materials and Methods: A total of 32 Female adult NMRI mice were divided into four groups. The control group (n=8) received vehicle, group 2 (n=8) received nicoti...

Background Theca cells play important roles during folliculogenesis. They synthesize androgens, provide crosstalk with granulosa cells and oocytes during development, and provide structural support of the growing follicle to produce a mature and fertilizable oocyte. In children patients who are going to be ovariectomy, follicogenesis is at early stage and thus the follicles need to be mature in...