نتایج جستجو برای: Fndc5

تعداد نتایج: 325  

2016
S. Barja-Fernández C. Folgueira C. Castelao O. Al-Massadi S. B. Bravo T. Garcia-Caballero R. Leis M. Pardo F. F. Casanueva L. M. Seoane

The fibronectin type III domain-containing protein 5 (FNDC5) discovered in 2002 has recently gained attention due to its potential role in protecting against obesity. In rat, no data exist regarding FNDC5 production and regulation in the stomach. The aim of the present work was to determine the expression of FNDC5 in the rat stomach and its potential regulation by body composition. The present ...

Journal: :Cell metabolism 2013
Christiane D Wrann James P White John Salogiannnis Dina Laznik-Bogoslavski Jun Wu Di Ma Jiandie D Lin Michael E Greenberg Bruce M Spiegelman

Exercise can improve cognitive function and has been linked to the increased expression of brain-derived neurotrophic factor (BDNF). However, the underlying molecular mechanisms driving the elevation of this neurotrophin remain unknown. Here we show that FNDC5, a previously identified muscle protein that is induced in exercise and is cleaved and secreted as irisin, is also elevated by endurance...

2017
Hyoung Kyu Kim Yu Jeong Jeong In-Sung Song Yeon Hee Noh Kyo Won Seo Min Kim Jin Han

Irisin is secreted by skeletal muscle during exercise and influences energy and metabolic homeostasis. This hormone is a cleaved and secreted fragment of fibronectin type III domain-containing 5 (FNDC5). Elucidation of the FNDC5 gene regulation mechanism is necessary to clarify the function of irisin as a potential therapeutic target in human metabolic diseases. Thus, we investigated the geneti...

2014
Katrin Komolka Elke Albrecht Lisa Schering Julia Brenmoehl Andreas Hoeflich Steffen Maak

The transmembrane protein FNDC5 was recently characterized as precursor of an exercise induced myokine named irisin. Previous studies found a relationship between circulating irisin levels and muscle mass in humans. Consequently, we tested the hypothesis whether FNDC5/irisin is involved in the modulation of body composition in cattle. Since information on the bovine FNDC5 locus was scarce, we c...

Journal: :International braz j urol : official journal of the Brazilian Society of Urology 2018
Diler Us Altay Esref Edip Keha Ersagun Karagüzel Ahmet Menteşe Serap Ozer Yaman Ahmet Alver

PURPOSES The aim of this study was to determine the diagnostic significance of fibronectin type III domain containing protein 5 (FNDC5)/Irisin levels in the sera of patients with renal cell cancer. MATERIALS AND METHODS In the study, 48 individuals were evaluated. The patient group included 23 subjects diagnosed with renal tumor, and the control group of 25 healthy individuals. Patients diagn...

Journal: :Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal 2023

Introduction: Age-related cognitive decline decreases with aerobic physical exercise in many animal models and humans. Irisin, a myokine its’ precursor FNDC5, has increased hippocampal development to improve learning memory. This study aims determine the association between irisin, activity enhancement of spatial adult mice. Methods: Three experimental studies will be conducted explore role FND...

2016
B. M. Varela-Rodríguez L. Pena-Bello P. Juiz-Valiña B. Vidal-Bretal F. Cordido S. Sangiao-Alvarellos

Irisin is processed from fibronectin type III domain-containing protein 5 (FNDC5). However, a controversy exists concerning irisin origin, regulation and function. To elucidate the relationship between serum irisin and FNDC5 mRNA expression levels, we evaluated plasma irisin levels and FNDC5 gene expression in the hypothalamus, gastrocnemius muscle and different depots of adipose tissue in mode...

2015
James S V Lally Rebecca J Ford Jasper Johar Justin D Crane Bruce E Kemp Gregory R Steinberg

Fibronectin type III domain-containing protein 5 (FNDC5) expression is controlled by the transcriptional co-activator, peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC1α). FNDC5 expression has been shown to be increased in muscle in response to endurance exercise in some but not all studies, therefore a greater understanding of the mechanisms controlling this process a...

2013
Silja Raschke Manuela Elsen Hans Gassenhuber Mark Sommerfeld Uwe Schwahn Barbara Brockmann Raphael Jung Ulrik Wisløff Arnt E. Tjønna Truls Raastad Jostein Hallén Frode Norheim Christian A. Drevon Tania Romacho Kristin Eckardt Juergen Eckel

Brown adipose tissue has gained interest as a potential target to treat obesity and metabolic diseases. Irisin is a newly identified hormone secreted from skeletal muscle enhancing browning of white fat cells, which improves systemic metabolism by increasing energy expenditure in mice. The discovery of irisin raised expectations of its therapeutic potential to treat metabolic diseases. However,...

2013
Arturo Roca-Rivada Cecilia Castelao Lucía L. Senin María O. Landrove Javier Baltar Ana Belén Crujeiras Luisa María Seoane Felipe F. Casanueva María Pardo

Exercise provides clear beneficial effects for the prevention of numerous diseases. However, many of the molecular events responsible for the curative and protective role of exercise remain elusive. The recent discovery of FNDC5/irisin protein that is liberated by muscle tissue in response to exercise might be an important finding with regard to this unsolved mechanism. The most striking aspect...

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