Dermatofibrosarcoma protruberans is a relatively uncommon slow growing, locally aggressive fibrous tumor of the skin. It has a prospensity of progressing to fibrosarcomatous change in 5% of the cases. We present a case of a 56 yr old male with presented to the outpatient department of surgery, Sri Siddhartha Medical College, Tumkur with a chest swelling in 2013. FNAC was inconclusive and the ma...

Dermatofibrosarcoma protruberans is a relatively uncommon slow growing, locally aggressive fibrous tumor of the skin. It has a prospensity of progressing to fibrosarcomatous change in 5% of the cases. We present a case of a 56 yr old male with presented to the outpatient department of surgery, Sri Siddhartha Medical College, Tumkur with a chest swelling in 2013. FNAC was inconclusive and the ma...

dermatofibrosarcoma protruberans is a relatively uncommon slow growing, locally aggressive fibrous tumor of the skin. it has a prospensity of progressing to fibrosarcomatous change in 5% of the cases. we present a case of a 56 yr old male with presented to the outpatient department of surgery, sri siddhartha medical college, tumkur with a chest swelling in 2013. fnac was inconclusive and the ma...

Dermatofibrosarcoma protuberans is a rare soft tissue neoplasm arising from mesenchymal cells, making up about 6% of all soft tissue tumours. Often found on the scalp, neck, trunk and extremities, it has an intermediateto low-grade malignancy potential except the fibrosarcomatous variant (high-grade), which is more likely to metastasize than other types. Here we present the case of a 46-year-ol...

Dermatofibrosarcoma protuberans (DFSP) is a relatively uncommon soft tissue tumor with intermediate-to-low grade malignancy. There is usually little nuclear pleomorfism and only low to moderate mitotic activity. Conventional DFSP, usually have fewer than 5 mitotic figures/10 high-power fields. We describe a case of a 74year old male patient who presented to the surgical clinic with active bleed...

Dermatofibrosarcoma protuberans (DFSP) is an unusual, locally aggressive, cutaneous neoplasm of low to intermediate grade malignant potential. Fibrosarcomatous DFSP (FS-DFSP), a rare variant of DFSP, has got a higher tendency for recurrence and metastasis resulting in significant morbidity and reduced survival. We present a case of this rare malignancy in a 23-year-old female who presented with...

Dermatofibrosarcoma protuberans with fibrosarcomatous transformation (DFSP-FS) is a rare variant, higher rates of recurrence and metastasis than DFSP. Detection the collagen type I alpha 1 (COL1A1)–platelet-derived growth factor beta chain (PDGFB) fusion gene useful for diagnosis In this letter, we report case DFSP-FS, focusing on expression COL1A1-PDGFB in lesions. Increased may be associated ...

To the Editor, Dermatofibrosarcoma protuberans (DFSP) is an uncommon sarcoma of the skin and soft tissue with an intermediate level of malignancy. DFSP with fibrosarcomatous differentiation (FS-DFSP) is a rare variant of DFSP, involving greater aggression, higher rates of local recurrences and a higher metastatic potential. We describe the case of a 70-year-old woman who presented with a painle...

We report the case of a young man diagnosed with dermatofibrosarcoma protuberans lung metastases seven years after primary tumor resection. Notably, no previous local recurrences had been observed. A multimodal approach was used for the management of this patient: surgery, radiotherapy and targeted therapy with Imatinib. The patient is alive with stable disease after thirty months of the metast...