Objective: Allium elburzense is an endemic plant of the family Amaryllidaceae that grows wild in northern Iran with some nutritional and medicinal applications. The present study was aimed to investigate the fibrinolytic and antioxidant effects of A. elburzense bulb extracts. Materials and Methods: Hydroalcoholic, aqueous, chloroformic and butanolic extracts were evaluated in this research. In ...

Fibrinolytic therapy has an expanding role in the treatment of many thromboembolic disorders. Four fibrinolytic drugs are currently marketed: streptokinase, anisoylated plasminogen-streptokinase activator complex, urokinase, and recombinant human tissue-type plasminogen activator. All 4 of these drugs activate the fibrinolytic system by converting plasminogen to the active enzyme, plasmin. Plas...

Introduction: Atherothrombotic diseases such as myocardial or cerebral infarction are serious consequences of the thrombus formation in blood vessels. Thrombolytic agents are used to dissolve the already formed clots in the blood vessels. However, these drugs have certain adverse effects, which cause serious and sometimes fatal consequences. Methods: Plants essential oils were prepared and ...

By A. E. D R AND D. Ku ui A GROWING INTEREST in fibrinolytic agents has given rise to a variety of methods for assessing the activity of such agents in vitro. The fibrin plate assay1 is a useful technic employing the natural substrate. Other methods,2 using formed fibrin clots, have also been devised, as well as technics employing other substrates such as casein. The purpose of this study was t...

By A. E. D R AND D. Ku ui A GROWING INTEREST in fibrinolytic agents has given rise to a variety of methods for assessing the activity of such agents in vitro. The fibrin plate assay1 is a useful technic employing the natural substrate. Other methods,2 using formed fibrin clots, have also been devised, as well as technics employing other substrates such as casein. The purpose of this study was t...

Tissue type plasminogen activator (t-PA) is an effective thrombolytic agent in experimental animals. The duration of the thrombolytic effect of infused t-PA is unknown. We compared the duration of the thrombolytic effect of t-PA with streptokinase by measuring the lysis of 125l-fibrinlabeled thrombi in rabbit jugular veins at different times after a bolus injection of the fibrinolytic agents. T...

T hrombosis is a dynamic process in which procoagulant activity, which promotes platelet activation and fibrin deposition, is balanced by physiologic anticoagulant and fibrinolytic activity. Historically, the treatment of thrombosis has been based on the use of agents that either inhibit procoagulant activity (i.e., anticoagulants) or induce fibrinolytic activity (i.e., plasminogen activators)....

BACKGROUND Fibrinolytic therapy is a time-critical intervention proven to reduce mortality and morbidity in patients with ST-elevation myocardial infarction (STEMI). Limited data exist in South Africa (SA) regarding time to fibrinolytic therapy for STEMI patients and reasons for delayed therapy. OBJECTIVES To establish the proportion of STEMI patients receiving fibrinolytic agents at Steve Bi...