Background: Sperm DNA damage (SDD) is a significant male infertility factor, yet it is not routinely diagnosed or treated in couples undertaking fertility treatment by ART. Men with this condition are likely to experience sub-fertility or infertility, expose their female partners to greater risk of miscarriage and pass on de novo sporadic DNA mutations potentially compromising the health of the...

Abstract Study question Can oral administration of antioxidants improve follicle survival in human ovarian tissue through reduction oxidative stress a xenotransplantation model? Summary answer Daily for 7 days post-transplantation had positive effect on grafted tissue. What is known already Today cryopreservation and autotransplantation an established fertility preservation method many centres....

Abstract Study question Do common chemicals in plastic, BPAF and DBP, negatively impact sperm parameters DNA integrity, can oral antioxidant supplementation mitigate their impact? Summary answer Short-term, low-dose exposure to or DBP did not testicular/epididymal histology but caudal epididymal parameters, particularly integrity was significantly compromised. What is known already Plasticizers...

The Sperm Chromatin Structure Assay (SCSA®) is the pioneering sperm DNA fragmentation assay that precisely measures the percent of sperm in a semen sample that have Sperm DNA Damage (SDD), a negative factor for successful pregnancy. The SCSA® is a rapid, dual parameter, computer driven assay with diligent unbiased flow cytometer measurements on five to ten thousand sperm per sample providing ri...