Objective: Forkhead box proteins and Forkhead box transcription factor O1 (FOXO1) in particular, mediate insulin signaling pathways and glucose homeostasis. This study aimed to compare FOXO1 expression in subcutaneous adipose (SA) tissue between obese rats with and without type 2 diabetes (T2D) and its response to resistance training in T2D. Materials and Methods: 21 male wistar rats (220±20 g...

Correction for “mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis,” by Mathieu Laplante and David Sabatini, which appeared in issue 8, February 23, 2010, of Proc Natl Acad Sci USA (107:3281–3282; first published February 18, 2010; 10.1073/pnas.1000323107). The authors note that, on page 3281, left column, second paragraph, the fourth sentence is incorrect in part. “In add...

In order to explore the role of forkhead box protein O1 (FoxO1) in lipid metabolism and cell proliferation, goose primary hepatocytes were isolated incubated with insulin or PI3K-Akt-mTOR pathway dual inhibitor NVP-BEZ235, then transfected FoxO1 interference plasmid. The related parameters proliferation measured. results firstly showed that increased intracellular TG lipids concentration (P < 0...

Forkhead box protein O1 (FOXO1) is a multifunctional transcription factor of the forkhead family. It may function as a tumor suppressor through its ability to regulate cellular events, including cell proliferation, apoptosis, and cell cycle control. As reported, FOXO1 is downregulated in papillary thyroid carcinoma (PTC). However, the function of FOXO1 in human PTC remains unclear. In this stud...

The present study aimed to explore the effects of α-cyperone, an extract Cyperus rotundus, on PC12 cells, as well underlying mechanism. Following cells were induced by oxygen-glucose deprivation/reoxygena-tion (OGD/R), viability, morphology, inflammation, oxidative stress and apoptotic levels in evaluated. To mechanism treated with 3-TYP, a sirtuin-3 (SIRT3) inhibitor, then 3-TYP function α-cyp...

Inhibitor of DNA-binding 1 (ID1) protein has been studied intensively for its functions in tumorigenesis and maintenance stem cell-like properties, but roles virus infection are less understood. In the present study, we have clearly shown that foot-and-mouth disease (FMDV) promotes ID1 degradation via Cdh1-mediated ubiquitination to facilitate replication. Mechanistic investigations reveal Fork...

The renin-angiotensin system is a major determinant of blood pressure regulation. It consists of a cascade of enzymatic reactions involving 3 components: angiotensinogen, renin, and angiotensin-converting enzyme, which generate angiotensin II as a biologically active product. Angiotensinogen is largely produced in the liver, acting as a major determinant of the circulating renin-angiotensin sys...

Keratinocyte mobilization is a critical aspect of wound re-epithelialization, but the mechanisms that control its precise regulation remain poorly understood. We set out to test the hypothesis that forkhead box O1 (FOXO1) has a negative effect on healing because of its capacity to inhibit proliferation and promote apoptosis. Contrary to expectations, FOXO1 is required for keratinocyte transitio...

Medulloblastoma is the most frequent type of childhood brain tumour. The insulin-like growth factor I receptor (IGF-IR) plays a significant neuroprotective role in medulloblastoma survival through regulation of the downstream effectors of the phosphoinositide-3-kinase-protein kinase-B (PI3K-PKB/c-Akt) pathway. One such target is Forkhead box O1 (FOXO1; FKHR), which is part of the FOXO family of...