Intraoperative frozen section (FS) evaluation of ureteral and urethral margins is frequently requested during radical cystoprostatectomy in patients with bladder urothelial carcinoma. However, it is still controversial whether intraoperative FSs of ureteral and urethral margins are necessary in all patients with cystoprostatectomy or a risk-based assessment with limited to the high risk patient...

Fast-spiking (FS) interneurons in the brain are self-innervated by powerful inhibitory GABAergic autaptic connections. By computational modelling, we investigate how autaptic inhibition regulates the firing response of such interneurons. Our results indicate that autaptic inhibition both boosts the current threshold for action potential generation as well as modulates the input-output gain of F...

INTRODUCTION Frasier syndrome (FS) is a genetic form of glomerulopathy, which results from mutations in the Wilms'tumour suppressor gene (WT1). Proteinuria in FS has been traditionally considered unresponsive to any medication and FS inevitably progresses to end stage renal failure. CASE OUTLINE We present a patient with FS who had atypical clinical manifestation and unusual beneficial antipr...

We report on an extended-cavity mode-locked laser based on an Yb:CALGO crystal operating either at 27 MHz and 93 fs pulse duration or at 15 MHz and 170 fs duration single-pulse regime. To the best of our knowledge this is the first demonstration of an extended-cavity oscillator based on Yb-doped crystal producing sub-100 fs pulses. The pulse energy was 24 nJ directly at the output of the oscill...

Background: The aim of this study was to determine 17 Polychlorinated Dibenzo-p-dioxin and Dibenzofuran (PCDD/F) and 12 Dioxin-like Polychlorinated Biphenyl (DL-PCB) concentrations in the tissues of Finnish terrestrial herbivore species, semi-domesticated reindeer (Rangifer tarandus tarandus L.), and wild moose (Alces alces), investigate transfer and accumulation of PCDD/Fs and DL-PCBs in milk ...

Inhibition from fast-spiking (FS) interneurons plays a crucial role in shaping cortical response properties and gating developmental periods of activity-dependent plasticity, yet the expression mechanisms underlying FS inhibitory plasticity remain largely unexplored. In layer 4 of visual cortex (V1), monocular deprivation (MD) induces either depression or potentiation of FS to star pyramidal ne...

Introduction Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) are ubiquitous, persistent, lipophilic pollutants in food. Ingestion of contaminated food is the principal way of human exposure to these compounds, Most data about human exposure to PCDD/Fs and dioxin-like PCBs were available from the industrialized countries 2 while the data from de...