In sheet metal forming processes with complex strain paths, a part is subjected to large plastic deformation. This severe plastic deformation leads to high plastic strain localization zones and subsequent accumulation of those strains. Then internal and superficial micro-defects and in other words ductile damage is created. This damage causes quality problems such as fracture. Therefore, design...

Up to now a large number of models have been developed to measure or predict the damage in equipments. Some of these models have been implemented in ABAQUS software. To implement damage parameters in the software, it is necessary to perform complex and expensive practical tests. One of these damage models is Forming Limit Diagram (FLD).The purpose of this research is deriving required parameter...

OBJECTIVE In familial lecithin:cholesterol acyltransferase (LCAT) deficiency (FLD), deposition of abnormal lipoproteins in the renal stroma ultimately leads to renal failure. However, fish-eye disease (FED) does not lead to renal damage although the causative mutations for both FLD and FED lie within the same LCAT gene. This study was performed to identify the lipoproteins important for the dev...

Background & AimsFatty liver disease (FLD) is a growing epidemic that expected to be the leading cause of end-stage within next decade. Both environmental and genetic factors contribute susceptibility FLD. Several variants contributing FLD have been identified in exome-wide association studies. However, there still missing hereditability indicating other are yet discovered.MethodsTo find genes ...

BACKGROUND & AIMS Red blood cell (RBC) indices have been demonstrated to be associated with fatty liver disease (FLD) and metabolic syndrome. However, controversy exists regarding the relationship of RBC indices with FLD to date and few has focused on RBC count. This study aimed to explore the association between RBC count and risk of FLD in Southern Chinese adults. METHODS A hospital-based c...

In this paper, a new approach is proposed for stress state - dependent flow localization in bifurcation failure model bounded through ductile damage in dynamically loaded sheets. Onset of localized necking is considered in phenomenological way for different strain rates to draw the forming limit diagram (FLD). Using a strain metal hardening exponent in the Vertex theory related to the strain ra...

The use of recombinant antigens has been shown to improve both the sensitivity and the standardization of the serological diagnosis of Farmer's lung disease (FLD). The aim of this study was to complete the panel of recombinant antigens available for FLD serodiagnosis with antigens of Lichtheimia corymbifera, known to be involved in FLD. L. corymbifera proteins were thus separated by 2D electrop...

Fatty liver disease (FLD) is characterized by lipid accumulation in hepatocytes and is accompanied by secretory pathway dysfunction, resulting in induction of the unfolded protein response (UPR). Activating transcription factor 6 (ATF6), one of three main UPR sensors, functions to both promote FLD during acute stress and reduce FLD during chronic stress. There is little mechanistic understandin...

Fatty liver disease (FLD) can be a precondition for other liver pathology including cholangiocarcinoma (CCA). Diabetes mellitus (DM) has been suggested in some studies to be a risk factor for FLD as well as cancers, including cholangiocellular carcinoma; however, there are currently very few studies on FLD in DM subjects, although the rate of FLD continues to increase annually. To determine the...

BACKGROUND Ferredoxin-NADP(H) reductase (FNR) from Pisum sativum and Flavodoxin (Fld) from Anabaena PCC 7119 have been reported to protect a variety of cells and organisms from oxidative insults. In this work, these two proteins were expressed in mitochondria of Cos-7 cells and tested for their efficacy to protect these cells from oxidative stress in vitro. PRINCIPAL FINDINGS Cos-7/pFNR and C...