The existing health care systems focus on treating diseases rather than preventing them. Patients are generally not tested unless physiological symptoms are appeared. When they do get tested, the results often take several days and can be inconclusive if the disease is at an early stage. In order to facilitate the diagnostics process and make tests more readily available for patients, the conce...

Sensitive and quantitative detection of tumor markers is highly required in the clinic for cancer diagnosis and consequent treatment. A field-effect transistor-based (FET-based) nanobiosensor emerges with characteristics of being label-free, real-time, having high sensitivity, and providing direct electrical readout for detection of biomarkers. In this paper, a top-down approach is proposed and...

Various biomaterials such as antibody, aptamer, enzyme, DNA and sensory receptor can be used for recognizing ligands by nanobiosensor. Especially, olfactory sensing elements with olfactory receptor are most promising one to develop the nanobiosensor with high performance because they can discriminate target molecules with high selectivity and also detect numerous odorant molecules, for example ...

Nitric oxide (NO) plays an essential role within the immune system since it is involved in the break-down of infectious agents such as viruses and bacteria. The ability to measure the presence of NO in the intracellular environment would provide a greater understanding of the pathophysiological mechanism of this important molecule. Here we report the detection of NO from the intracellular phago...

Background & aim: In addition to the benefits of frozen embryo transfer (FET), the key question is whether freezing or melting embryos can cause fetal harm and prenatal complications. This study aimed to assess pregnancy and neonatal outcomes after FET and fresh embryo transfer (ET). Methods: This retrospective ...

This study aims to evaluate the feasibility of a label-free nanobiosensor based on blood plasma surface-enhanced Raman spectroscopy (SERS) method for exploring variability of different tumor (T) stages in nasopharyngeal cancer (NPC). Au nanoparticles as the SERS-active nanostructures were directly mixed with human blood plasma to enhance the Raman scattering signals. High quality SERS spectra c...

Nanotechnology has emerged as a boon to the society with immense potential in varied area of research and our dayto-day life. The application of nanotechnology for the advancement of biosensor leads to an efficient nanobiosensor with miniature structure as compared to conventional biosensors. Nanobiosensors can be effectively used for sensing a wide variety of fertilizers, herbicide, pesticide,...

BACKGROUND O-(2-18 F-fluoroethyl)-L-tyrosine-(FET)-PET may be helpful to improve the definition of radiation target volumes in glioblastomas compared with MRI. We analyzed the relapse patterns in FET-PET after a FET- and MRI-based integrated-boost intensity-modulated radiotherapy (IMRT) of glioblastomas to perform an optimized target volume definition. METHODS A relapse pattern analysis was p...

Personalized medicine is a promising tool not only for prevention, screening and development of more efficient treatment strategies, but also for diminishing the side effects caused by current therapies. Deciphering gene regulation pathways provides a reliable prognostic analysis to elucidate the origin of grave diseases and facilitate the selection of the most adequate treatment for each indiv...