An exact Filter Design Optimization (FDO) algorithm that can guarantee the minimum design complexity, but can only be applied to filters with a small number of coefficients. Then introduce multiple constant multiplications and using exact and approximate algorithm that can handle filters with a large number of coefficients using less computational resources than the exact FDO algorithm and find...

Feedback-driven program optimization (FDO) is common in modern compilers, including Just-In-Time compilers increasingly adopted for object-oriented or scripting languages. This paper describes a systematic study in understanding and alleviating the effects of sampling errors on the usefulness of the obtained profiles for FDO. Taking a statistical approach, it offers a series of counter-intuitiv...

This thesis makes improvement to the process of ahead-of-time feedback-directed optimization (FDO) in compiler design. It examines multiple aspects of FDO from profile collection and representation through to the performance evaluation of FDO code transformations. Two guiding principals knit the four components of the research together. The first principle is a recognition that program behavior...

BACKGROUND Excessive femoral anteversion is common in cerebral palsy (CP), is often associated with internal hip rotation during gait, and is frequently treated with a femoral derotational osteotomy (FDO). Concerns exist regarding long-term maintenance of surgical outcomes. Past studies report varying rates of recurrence, but none have employed a control group. METHODS We conducted a retrospe...

The formation of spatially repetitive structures along the growth axis of a developing embryo is a common theme in developmental biology. Here we apply the novel flow-distributed oscillator (FDO) mechanism of wave pattern formation to the problem of axial segmentation in general and to somitogenesis in particular. We argue that the conditions for formation of FDO waves are satisfied during somi...

Traditional feedback-directed optimization (FDO) in GCC uses static instrumentation to collect edge and value profiles. This method has shown good application performance gains, but is not commonly used in practice due to the high runtime overhead of profile collection, the tedious dual-compile usage model, and difficulties in generating representative training data sets. In this paper, we show...

BACKGROUND Fingolimod is the first oral disease-modifying therapy indicated for the treatment of patients with relapsing forms of multiple sclerosis (MS) to reduce the frequency of clinical relapses and delay the progression of physical disability caused by MS. OBJECTIVE To obtain data from MS patients who have taken fingolimod regarding their treatment choice, first-dose observation (FDO) ex...

In Germany there is much agreement on a necessary step towards convergence in the domain of digital entities across sectors given increasing number emerging data spaces research, industry and public services. Therefore group FAIR Digital Objects (FDO) experts working proposal that will demonstrate functionality FDOs, their added value scalability components, establish an active FDO community di...

Feedback-directed optimization (FDO) is a general term used to describe any technique that alters a program’s execution based on tendencies observed in its present or past runs. This paper reviews the current state of affairs in FDO and discusses the challenges inhibiting further acceptance of these techniques. It also argues that current trends in hardware and software technology have resulted...

PURPOSE Poor motor control and delayed thumb function and a delay in walking are the main factors which retard the natural decrease of the femoral anteversion (FA) with age. In addition, cerebral palsy (CP) patients usually have muscular imbalance around the hip as well as muscle contractures, both of which are main factors accounting for the increased FA which is commonly present in CP patient...