نتایج جستجو برای: FABP4

تعداد نتایج: 703  

2014
Yusuke Okazaki Masato Furuhashi Marenao Tanaka Tomohiro Mita Takahiro Fuseya Shutaro Ishimura Yuki Watanabe Kyoko Hoshina Hiroshi Akasaka Hirofumi Ohnishi Hideaki Yoshida Shigeyuki Saitoh Kazuaki Shimamoto Tetsuji Miura

BACKGROUND Fatty acid-binding protein 4 (FABP4/A-FABP/aP2) is expressed in not only adipocytes and macrophages but also peritubular capillaries in the normal kidney. We recently demonstrated that ectopic expression of FABP4, but not FABP1 known as liver FABP (L-FABP), in the glomerulus is associated with progression of proteinuria and renal dysfunction. However, urinary excretion of FABP4 has n...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2016
Masato Furuhashi Takahiro Fuseya Masaki Murata Kyoko Hoshina Shutaro Ishimura Tomohiro Mita Yuki Watanabe Akina Omori Megumi Matsumoto Takeshi Sugaya Tsuyoshi Oikawa Junichi Nishida Nobuaki Kokubu Marenao Tanaka Norihito Moniwa Hideaki Yoshida Norimasa Sawada Kazuaki Shimamoto Tetsuji Miura

OBJECTIVE Fatty acid-binding protein 4 (FABP4) is expressed in adipocytes and macrophages, and elevated circulating FABP4 level is associated with obesity-mediated metabolic phenotype. We systematically investigated roles of FABP4 in the development of coronary artery atherosclerosis. APPROACH AND RESULTS First, by immunohistochemical analyses, we found that FABP4 was expressed in macrophages...

Journal: :Genetics and molecular research : GMR 2013
S Wei L S Zan H B Wang G Cheng M Du Z Jiang G J Hausman D C McFarland M V Dodson

Fatty acid binding protein 4 (FABP4) is an important adipocyte gene, with roles in fatty acid transport and fat deposition in animals as well as human metabolic syndrome. However, little is known about the functional regulation of FABP4 at the cellular level in bovine. We designed and selected an effective shRNA (small hairpin RNA) against bovine FABP4, constructed a corresponding adenovirus (A...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017
Peng Wang Qiuyuan Zhu Huilian Peng Mengkai Du Minyue Dong Hanzhi Wang

AIMS To clarify the role of fatty acid-binding protein 4 (FABP4) of endometrial epithelial cell in the establishment and maintenance of pregnancy and the involvement in the pathogenesis of pregnancy loss. METHODS The expression of FABP4 and uterine receptive factor (LIF, Integrin-β3 and Claudin 4) was determined by Western blotting or quantitative PCR. FABP4 siRNA was used to silence FABP4 wh...

2017
Yong‐Soo Lee Ja‐Yeon Kim Kyung‐Soo Oh Seok Won Chung

BACKGROUND Fatty infiltration in skeletal muscle is directly linked to loss of muscle strength and is associated with various adverse physical outcomes such as muscle atrophy, inflammation, insulin resistance, mobility impairments, and even mortality in the elderly. Aging, mechanical unloading, muscle injury, and hormonal imbalance are main causes of muscle fat accumulation, and the fat cells a...

Journal: :European journal of endocrinology 2011
Ximena Terra Yunuen Quintero Teresa Auguet Jose Antonio Porras Mercé Hernández Fátima Sabench Carmen Aguilar Anna María Luna Daniel Del Castillo Cristobal Richart

OBJECTIVE The adipocyte/macrophage fatty acid-binding protein 4 (FABP4) has been described as a biomarker for adiposity and metabolic syndrome (MS). The aims of this study were to assess the relationship between FABP4 and inflammatory cytokines related to obesity, and to evaluate FABP4 mRNA expression in visceral and subcutaneous adipose tissue in non-diabetic morbidly obese women versus health...

Journal: :Diabetes 2014
Tali Garin-Shkolnik Assaf Rudich Gökhan S Hotamisligil Menachem Rubinstein

Fatty acid binding protein 4 (FABP4, also known as aP2) is a cytoplasmic fatty acid chaperone expressed primarily in adipocytes and myeloid cells and implicated in the development of insulin resistance and atherosclerosis. Here we demonstrate that FABP4 triggers the ubiquitination and subsequent proteasomal degradation of peroxisome proliferator-activated receptor γ (PPARγ), a master regulator ...

2013
Anna Cabré Pilar Valdovinos Iolanda Lázaro Gil Bonet Alfredo Bardají Lluís Masana

BACKGROUND Circulating adipocyte fatty acid-binding protein (FABP4) levels are considered to be a link between obesity, insulin resistance, diabetes, and cardiovascular (CV) diseases. In vitro, FABP4 has exhibited cardiodepressant activity by suppressing cardiomyocyte contraction. We have explored the relationship between FABP4 and the N-terminal fragment of pro-B-type natriuretic peptide (NT-p...

2011
Sverre Holm Thor Ueland Tuva B. Dahl Annika E. Michelsen Mona Skjelland David Russell Ståle H. Nymo Kirsten Krohg-Sørensen Ole Petter Clausen Dan Atar James L. Januzzi Pål Aukrust Jesper K. Jensen Bente Halvorsen

BACKGROUND AND PURPOSE Fatty acid binding protein 4 (FABP4) has been shown to play an important role in macrophage cholesterol trafficking and associated inflammation. To further elucidate the role of FABP4 in atherogenesis in humans, we examined the regulation of FABP4 in carotid atherosclerosis and ischemic stroke. METHODS We examined plasma FABP4 levels in asymptomatic (n = 28) and symptom...

Journal: :The Biochemical journal 2013
Meixiu Jiang Ling Zhang Xingzhe Ma Wenquan Hu Yuanli Chen Miao Yu Qixue Wang Xiaoju Li Zhinan Yin Yan Zhu Xiumei Gao David P Hajjar Yajun Duan Jihong Han

Macrophage adipocyte fatty acid-binding protein (FABP4) plays an important role in foam cell formation and development of atherosclerosis. Tamoxifen inhibits this disease process. In the present study, we determined whether the anti-atherogenic property of tamoxifen was related to its inhibition of macrophage FABP4 expression. We initially observed that tamoxifen inhibited macrophage/foam cell ...

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