Physical drug delivery through smart nanocarrier and external stimulus could lead to significant improvements of drug potency as well as noticeable decrease in unwanted side effects. Currently, many external energy sources such as light, magnetic fields, ultrasound, ...,  are under investigation as external stimulus for physical drug delivery. The purpose of this paper is to review most recent ...

background: to evaluate safety and efficacy of percutaneous release of trigger finger in multiple digits involvement in comparison with  single digit involvement.   method: a number of 100 patients (131 fingers) were treated by percutaneous release and divided into two groups: single digit (group a) and multiple digits (group b). they were followed up for one year. success rate, pain, complicat...

  Background: To evaluate safety and efficacy of percutaneous release of trigger finger in multiple digits involvement in comparison with  single digit involvement.   Method: A number of 100 patients (131 fingers) were treated by percutaneous release and divided into two groups: single digit (group A) and multiple digits (group B). They were followed up for one year. Success rate, pain, complic...

Paediatric bilateral multiple trigger fingers are extremely rare. The underlying etiopathogenesis and hence the surgical principles of management of trigger finger in children are different from those of pediatric trigger thumb and adult trigger finger. In this paper, we report the case of a 5 year old girl with congenital trigger digits involving the middle, ring and little fingers of both han...

Shapeshifting enables a wide range of engineering and biomedical applications, but until now transformations have required external triggers. This prerequisite limits viability in closed or inert systems and puts forward the challenge of developing materials with intrinsically encoded shape evolution. Herein we demonstrate programmable shape-memory materials that perform a sequence of encoded a...

Conventional chemotherapy for the treatment of cancer has limited specificity when administered systemically and is often associated with toxicity issues. Enhanced accumulation of polymeric nanocarriers at a tumor site may be achieved by passive and active targeting. Incorporation of trigger responsiveness into these polymeric nanocarriers improves the anticancer efficacy of such systems by mod...