an in vitro study on the role of intracellular calcium ions in healing of excisional wound in rabbit was undertaken. we employed two drugs namely, glibenclamide and nitroglycerin that are topically applied in vivo to modulate the activity of intracellular calcium. our model consisted of a 15 ´ 15 mm excisional wound. seven groups of new zealand rabbits were used. the first three groups served a...

Objective is to investigate the effect of topical tinospora cordifolia (TC) on excisional wound in albino rats. Excisional wounds were inflicted by excising the full thickness circular skin (approximately 500 mm) from the nape of neck in albino rats under light ether anesthesia taking aseptic precautions. Treatment group received 1% tinospora cordifolia cream for 16 days from the day of woundin...

Staphylococcus aureus is a virulent pathogen and a major causative agent of superficial and invasive skin and soft tissue infections (SSSTIs). Antibiotic resistance in S. aureus, among other bacterial pathogens, has rapidly increased, and this is placing an enormous burden on the health care sector and has serious implications for infected individuals, especially immunocompromised patients. Alt...

Rodents have robust wound healing mechanism compared to other animal species. The major mechanisms of wound healing differ between rodents and humans. In humans, wound healing primarily depends on re-epithelialization and granulation tissue (GT) formation, whereas wound contraction is more important during rodent wound closure. In this study, we described a novel excisional wound-splinting mode...

Healing of skin wound is a multi-factorial and complex process. Proper treatment of diabetic wounds is still a major clinical challenge. Although diabetes mellitus can occur in ruminants, healing of wounds in diabetic ruminants has not yet been investigated. The aim of this study was to evaluate healing of ovine excisional diabetic wound model. Eight 4-month-old Iranian Makoui wethers were equa...

The response to major burn injury includes systemic release of mediators that may have an effect on wound healing. The authors evaluated the effect of a burn injury on the contraction of an excisional wound adjacent to the burn, and the effect of plasma derived from burn-injured animals on the contraction of the fibroblast-populated collagen matrix (FPCM). Nine rats (90-100 days old) under anes...

Introduction: Re-epithelialisation of cutaneous wounds is a complex multistep process. In partial thickness wounds, keratinocytes from wound edges and the remnants of the epidermal appendages contribute to the process. We investigated whether the mechanism of injury had any influence on reepithelialisation of partial thickness wounds in a porcine model. Method: Partial thickness wounds were cre...

healing of skin wound is a multi-factorial and complex process. proper treatment of diabetic wounds is still a major clinical challenge. although diabetes mellitus can occur in ruminants, healing of wounds in diabetic ruminants has not yet been investigated. the aim of this study was to evaluate healing of ovine excisional diabetic wound model. eight 4-month-old iranian makoui wethers were equa...