Co-processing an active pharmaceutical ingredient (API) with a low Tg excipient has been previously reported to be an effective strategy for preventing drug amorphisation on milling. This technique relies on the ability of the excipient to form a molecular dispersion with the amorphous API during the milling process. The presence of the excipient within the amorphous phase induces a reduction o...

objective(s):the aim of this study was to improve flowability and compressibility characteristics of starch to use as a suitable excipient in direct compression tabletting. quasi-emulsion solvent diffusion was used as a crystal modification method. materials and methods: corn starch was dissolved in hydrochloric acid at 80˚c and then ethanol as a non-solvent was added with lowering temperature ...

Pharmaceutical formulation development involves various components in addition to the active pharmaceutical ingredients. In recent years, excipient development is become core area of research in pharmaceutical drug delivery because it influences the formulation development and drug delivery process in various ways. Biopolymers are choice of research as excipient because of its low toxicity, bio...

The effect of dosing vehicle excipients such as PEG400, propylene glycol, Tween 80, and hydroxypropyl-beta-cyclodextrin on the accuracy of LC/MS measurements used in pharmacokinetic studies is examined. Using PEG400 as a probe compound, the concentration-time profile of the excipient in plasma from rats dosed both orally and intravenously is determined. These excipient plasma concentrations can...

Recent years have seen a marked diversification of excipient based formulation strategies used for the development and commercialisation of dry powder inhaler (DPI) products. These innovative approaches not only provide benefits to patients and health care professionals through the availability of a wider range of therapeutic DPI products, but, importantly, also allow formulators to exploit the...

Interest in use of the polysaccharide chitosan as a pharmaceutical excipient by different dose routes and for a number of applications is not new but it still does not appear to be present in any marketed drugs. Also a novel excipient in a new formulation requires a lot of safety consideration. Published literature showed that chitosan has low oral toxicity and prior human exposure has occurred...

The objective of the current research article is to provide a comprehensive review of excipients impact on the stability of the drug product and their implications during the product development. Recent developments in the understanding of the degradation pathways further impact methodologies used in the pharmaceutical industry for potential stability assessment. The formation of drug excipient...

The oral bioavailability of many bioactives (pharmaceuticals, dietary supplements, nutrients, and nutraceuticals) is limited because of physicochemical and physiological events that occur within the gastrointestinal tract (GIT) after their ingestion. These events include: (i) restricted liberation from drugs, supplements, or foods; (ii) extensive metabolism or chemical transformation during pas...

Allergic reactions to mannitol have been reported rarely, despite its widespread use as a drug and as a food excipient. This is the first case report in which oral mannitol induces an immediate type hypersensitivity as a drug excipient, in a 42 year old man affected by rhinitis to olive tree pollen. Unusual and undervalued risk factors for mannitol hypersensitivity are examined.

Direct compression is the preferred method for the preparation of tablets. Co-processing is the one of the most widely explored and commercially utilized method for the preparation of directly compressible vehicles. The objective of the present study is to prepare and characterize pregelatinized starch-poly vinyl pyrrolidone (PGS-PVP) co-processed excipient and to evaluate its application as di...