Etoposide, a widely used anticancer drug, exhibits low and variable oral bioavailability mainly because of being substrate for the efflux transporter, P-glycoprotein (P-gp). Therefore, the present study was aimed to investigate the effect of D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) and PEG 400 as P-gp inhibitors on the intestinal absorption of etoposide. Everted sacs of rat smal...

aim : in this paper effect of combinational usage of calprotectin and etoposide on ags cell line is studied. background : application of combined toxic agents such as etoposide and cicplatin are commonly used for chemotherapy purposes. as a matter of fact, calprotectin and etoposide were both applied on human gastric adenocarcinoma cell line (ags) as antitumor agents. both calprotectin and etop...

background: the activity and toxicity of etoposide in women with recurrent ovarian cancer was evaluated in a case series of women with recurrent ovarian cancer who had measurable disease, methods: all patients had plior platinum-based chemotherapy and developed progressive disease, etoposide was given as 50mg/day for 21 days every 4 weeks until progression of disease or prohibitive toxicity, be...

Etoposide, a widely used anticancer drug, exhibits low and variable oral bioavailability mainly because of being substrate for the efflux transporter, P-glycoprotein (P-gp). Therefore, the present study was aimed to investigate the effect of D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) and PEG 400 as P-gp inhibitors on the intestinal absorption of etoposide. Everted sacs of rat smal...

abstract background: chemotherapy by using agents such as etoposide is a common way for inhibition of tumors. this treatment is accompanied by many undesirable side effects. calprotectin is an abundant protein in the neutrophil cytosol, it has growth-inhibitory and apoptosis-inducing activities against various cell types such as tumor cells. in this study to introduce calprotectin as a suitable...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 one of the prominent types of connective tissue cells is fibroblast that synthesizes and maintains the extracellular matrix of many animal tissues. previous studies illustrated that calprotectin protein has different cytotoxicity effects on fibroblast cells. calprotectin is abundant in the neutrophil cytosol; it has growth...

Background: The activity and toxicity of etoposide in women with recurrent ovarian cancer was evaluated in a case series of women with recurrent ovarian cancer who had measurable disease, Methods: All patients had plior platinum-based chemotherapy and developed progressive disease, Etoposide was given as 50mg/day for 21 days every 4 weeks until progression of disease or prohibitive toxicit...

etoposide, a widely used anticancer drug, exhibits low and variable oral bioavailability mainly because of being substrate for the efflux transporter, p-glycoprotein (p-gp). therefore, the present study was aimed to investigate the effect of d-α-tocopherol polyethylene glycol 1000 succinate (tpgs) and peg 400 as p-gp inhibitors on the intestinal absorption of etoposide. everted sacs of rat smal...

A series of 2-amino-4-(nitroalkyl)-4H-chromene-3-carbonitriles were synthesized by an efficient multicomponent reaction in aqueous media using DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) as a catalyst at room temperature. Mild condition, environment friendly procedure and excellent yields are the main advantages of this procedure. The cytotoxic activity of target compounds were evaluated against t...

Etoposide phophate is a phosphate ester prodrug of etoposide designed to improve the pharmaceutical characteristics of the parent compound. A Phase I dose-escalating study of etoposide phosphate was conducted concurrently at two institutions to determine its toxicity, pharmacokinetics, and maximum tolerated dose. Etoposide phosphate was administered i.v. for 30 min on days 1, 3, and 5 every 21 ...