extended release formulation of alfuzosin, an a-antagonist used for prostatic hypertrophy, is available in market. it is convenient for older patients to take only one tablet a day. marketed alfuzosin formulation is three layered geomatrix tablet that requires special facilities, high cost, more time and complex operation than normal direct compression formulation. therefore, a less complicated...

losartan potassium is a well known orally active non-peptide angiotensin ii receptor antagonist. losartan potassium and its principle active metabolites block the vasoconstrictor and aldosterone secreting effect of angiotensin ii by selectively blocking the binding of angiotensin ii to at1 receptors. the drug is reported to promote the decrease in ventricular hypertrophy, salt and water excreti...

the purpose of this study was to prepare and characterize nimodipine loaded microspheres using ethyl cellulose (ec) as a carrier polymer through an emulsion solvent evaporation method. these evaluations characterized the pattern of drug release from prepared microspheres. nimodipin loaded microspheres were prepared using an emulsification solvent evaporation method. the effect of process variab...

nifedipine (nif), a 1,4-dihydropyridine calcium channel antagonist, undergoes photo-degradation to dehydro-nifedipine (dnif) upon exposure to ultraviolet (uv) light and to the nitroso analogue of dehydro-nifedipine (ndnif) when exposed to sunlight or some kinds of artificial lights. nif photo-degradation products do not contribute to clinical activity, thus prevention of photo-degradation of ni...

For the design and development of any novel formulation, assessment of compatibility of drug with excipients by different techniques such as thermal and isothermal stress testing are recommended. During pre-formulation studies common methods like UV-Spectrophotometric methods, FTIR are used for the study of compatibility. In the present investigation drug-excepient compatibility study of was co...

The aim of this study was to develop and optimize a segregation-free ethyl cellulose-coated extended release multiparticulate formulation to be compressed into tablets without affecting the drug release. Standard tableting excipients (e.g., microcrystalline cellulose, lactose or sorbitol) were layered onto ethyl cellulose-coated propranolol hydrochloride pellets to form a cushion layer in order...

A study has been carried out to assess the potential use of pectin in combination with two added hydrocolloids, i.e., hydroxy-propyl-methyl cellulose and hydroxyethyl cellulose in varied concentrations and coated with ethyl cellulose and cellulose acetate phthalate. The results of in vitro drug release showed that the matrix tablets prepared with pectin, hydroxy ethyl cellulose (20 percent) whe...

Static headspace gas chromatographic (SHS-GC) analysis was performed to determine the release of 13 odorants in hydrocolloid model systems containing original or regio-selectively carboxylated cellulose at different pH values. The release of most odor compounds was decreased in the hydrocolloid solutions compared to control, with the amounts of 2-propanol, 3-methyl-1-butanol, and 2,3-butanedion...

The main objective of the work is to prepare mefenamic acid loaded microspheres for sustained release using different polymers ethyl cellulose as synthetic polymer and sodium alginate as natural polymer and compare and selecting best suitable polymer among them. For preparing mefenamic acid microspheres ethyl cellulose used as synthetic polymer in solvent evaporation method and sodium alginate ...