The title compound, C(24)H(22)O(4)S, was prepared by reaction between (2E)-3-(6-meth-oxy-2-naphth-yl)-1-(2-thien-yl)prop-2-en-1-one and ethyl acetoacetate. In the crystal, the cyclo-hexenone ring shows a distorted half-chair conformation. The length of the double bond in the cyclohexenone ring [1.343 (4) Å] is normal.

Anilines 1a-h on reaction with potassium thiocyanate and bromine in acetic acid yielded substituted 2-amino[2,1-b][1,3]benzothiazoles 3a-h. The compounds 3a-h on reaction with ethyl acetoacetate and pheylidine acetoacetate, yielded, 2-methyl-4-H-pyrimido[2,1b][1,3]benzothiazole-4-ones 4a-h and ethyl 4-phenyl-2-methyl-4H–pyrimido[2,1b][1,3]benzothiazole-3-carboxylates 5a-h respectively. Pheylidi...

We investigated the formation of delta-aminolevulinic acid (ALA)-pyrrole and subsequent color development used in determining ALA in urine. Of three condensation reagents examined--acetylacetone, ethyl acetoacetate, and methyl acetoacetate--the last was the best. When the ALA-pyrrole is reacted with Ehrlich's reagent in ethyl acetate according to one procedure, the optimum concentration of perc...

The mechansim of the three-component Biginelli dihydropyrimidine synthesis was reinvestigated using (1)H and (13)C NMR spectroscopy. Condensation of benzaldehyde, ethyl acetoacetate, and urea (or N-methylurea) in CD(3)OH according to the procedure described by Biginelli produced the expected 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates. According to NMR measurements, ther...

One pot syntheses of furan, thiophene, and pyrrole were accomplished by oxidative deacetylation using Mn(III)/Co(II) catalysts and the Paal-Knorr reaction from 1,5-dicarbonyl compounds, which are prepared from the conjugate addition of ethyl acetoacetate to α,β-unsaturated carbonyl compounds. The oxidative deacetylation and reductive cyclization of β-ketoesters derived from ethyl acetoacetate a...

Protein modification (sometimes known as crosslinking) often requires two or more steps to affix a small molecule irreversibly. Two-step reductive alkylation of the enzyme rabbit muscle aldolase with ethyl 3-C-acetoacetate and sodium cyanoborohydride attaches less radioactivity than with cyanoborohydride omitted. The C level incorporated into aldolase corresponds to only about 15–30 modified pr...

3-Methyl-1-phenylpyrazol-5-one and its derivatives prepared using ethyl acetoacetate, phenyl hydrazine and its derivatives. Ethyl acetoacetate reacted with phenylhydrazine at reflux temperature to give 3-methyl-1-phenylpyrazol-5-one crude and recrystlized from diluted ethanol to give pure 3-methyl1-phenylpyrazol-5-one. Different pyrazolone derivatives were prepared by using different phenyl hyd...