نتایج جستجو برای: Epiderm

تعداد نتایج: 71  

2011
John Mark Christensen Monica Chang Chuong Hang Le Loan Pham Ehab Bendas

OBJECTIVES: The penetration of hydrocortisone (HC) from six topical over-the-counter products along with one prescription cream through cultured normal human-derived epidermal keratinocytes (Epiderm™), mouse skin and synthetic nylon membrane was performed as well as the effect hydrating the skin by pre-washing was explored using the Upright Franz Cell. METHOD AND RESULTS: Permeation of HC throu...

2016
Soňa Jantová Dominika Topoľská Michaela Janošková Miroslav Pánik Viktor Milata

The new synthetically prepared quinolone derivative 7-ethyl 9-ethyl-6-oxo-6,9-dihydro[1,2,5]selenadiazolo [3,4-h]quinoline-7-carboxylate (E2h) showed in our previous study cytotoxic effects towards tumor cells and immunomodulatory activities on RAW 264.7 cell line murine macrophages. E2h may have a potential use as a novel chemotherapeutic agent with immunomodulatory properties and the ability ...

Journal: :Alternatives to laboratory animals : ATLA 2007
Horst Spielmann Sebastian Hoffmann Manfred Liebsch Phil Botham Julia H Fentem Chantra Eskes Roland Roguet José Cotovio Thomas Cole Andrew Worth Jon Heylings Penny Jones Catherine Robles Helena Kandárová Armin Gamer Marina Remmele Rodger Curren Hans Raabe Amanda Cockshott Ingrid Gerner Valérie Zuang

ECVAM sponsored a formal validation study on three in vitro tests for skin irritation, of which two employ reconstituted human epidermis models (EPISKIN, EpiDerm), and one, the skin integrity function test (SIFT), employs ex vivo mouse skin. The goal of the study was to assess whether the in vitro tests would correctly predict in vivo classifications according to the EU classification scheme, "...

Journal: :ALTEX 2004
Helena Kandárová Manfred Liebsch Elke Genschow Ingrid Gerner Dieter Traue Birgitta Slawik Horst Spielmann

An ECVAM-funded prevalidation study (PV) was conducted during 1999 and 2000 to identify in vitro tests capable of reliably distinguishing between skin irritants (I) and non-irritants (NI) according to European Union risk phrases ("R38" or no classification). The tests evaluated were EpiDerm, EPISKIN, PREDISKIN, the non-perfused pig ear method, and the mouse skin integrity function test (SIFT). ...

Journal: :Experimental dermatology 2010
Yanrong Su Jarah A Meador Charles R Geard Adayabalam S Balajee

Knowledge of cellular responses in tissue microenvironment is crucial for the accurate prediction of human health risks following chronic or acute exposure to ionizing radiation (IR). With this objective, we investigated the radio responses for the first time in three-dimensional (3D) artificial human skin tissue microenvironment after gamma-rays radiation. IR-induced DNA damage/repair response...

2015
Yoshihiro Tokudome Mishina Katayanagi Fumie Hashimoto

BACKGROUND Reconstructed human epidermal culture skin models have been developed for cosmetic and pharmaceutical research. OBJECTIVE This study evaluated the total and carboxyl esterase activities (i.e., Km and Vmax , respectively) and localization in two reconstructed human epidermal culture skin models (LabCyte EPI-MODEL [Japan Tissue Engineering] and EpiDerm [MatTek/Kurabo]). The usefulnes...

Journal: :Burns : journal of the International Society for Burn Injuries 2009
Huseyin Karagoz Fuat Yuksel Ersin Ulkur Rahmi Evinc

We compared the efficacy of silicone gel (Scarfade), silicone gel sheet (Epi-Derm), and topical onion extract including heparin and allantoin (Contractubex) for the treatment of hypertrophic scars. Forty-five postburn scars were included in the study. Patients with scars less than 6 months from injury were assigned at random to three groups each containing 15 scars, and their treatment was cont...

2013
J. M. F. G. Aerts A. W. Schram

Vacuoles were isolated from the upper epiderm is o f petals o f Petunia hybrida line R27 using three different procedures. Utilizing the vacuolar localization o f anthocyanin, vacuolar prep­ arations obtained through polybase treatment, osm otic shock and m echanical forces were com ­ pared on purity, yield and stability. The comparison indicated that application o f the polybase procedure resu...

2002
Valérie Zuang Michael Balls Philip A. Botham Alain Coquette Emanuela Corsini Rodger D. Curren Graham R. Elliott Julia H. Fentem Jon R. Heylings

The European Centre for the Validation of Alternative Methods (ECVAM) Skin Irritation Task Force, established in November 1996, prepared a report on the current status of the development and validation of alternative tests for skin irritation and corrosion in 1998 (1). The report focused on the identification of appropriate non-animal tests for predicting human skin irritation, which could be c...

2010
David Mitchell Lakshmi Paniker Guillermo Sanchez Zsolt Bella Edina Garaczi Marta Szell Qutayba Hamid Lajos Kemeny Andrea Koreck

Ultraviolet radiation (UVR) phototherapy is a promising new treatment for inflammatory airway diseases. However, the potential carcinogenic risks associated with this treatment are not well understood. UV-specific DNA photoproducts were used as biomarkers to address this issue. Radioimmunoassay was used to quantify cyclobutane pyrimidine dimers (CPDs) and (6-4) photoproducts in DNA purified fro...

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