it is believed that the inhibition of carbohydrate hydrolyzing enzymes including α-amylase and α-glucosidase is one of the therapeutic approaches to decrease the postprandial glucose level after a meal, especially in the people with type 2 diabetes. medicinal plants and their extracts are one of the main sources to find new inhibitors to the enzymes. in our study four flavonoids, namely luteoli...

mercury is one of the three major environmental metal poisons, and mercuric chloride is a highly reactive compound which can harm cells by a variety of mechanisms including direct interaction with sulphydryl groups of proteins and enzymes, therefore affecting the enzymatic activity. this study focused on the effect of hg++ on horseradish peroxidase (donor: hydrogen peroxide oxidoreductase, ec 1...

the aim of the present work was to purify cysteine protease inhibitors from rapeseed (brassica napus l.), with potential activity on digestive protease of colorado potato beetle (cpb), leptinotarsa decemlineata (say). ammonium sulfate precipitated proteinaceous fractions; 30, 50, 70, and 100% showed 39.07, 57.03, 51.47, and 22.44% inhibition on the fourth instar larval gut general protease acti...

derivatives of phenyl-keto butenoic acids have been reported to be inhibitors of pyruvate decarboxylase, (pdc). the inhibition of transketolase, a thiamine requiring enzyme such as pdf, by meta nitrophenyl derivative of 2-oxo-3-butenoic acid (mnpb) is reported here. these studies indicate that the inhibitor binds to the enzyme at the active site. a two-step inhibition was observed, first the in...

background: myeloperoxidase (mpo), which is abundantly expressed in neutrophils, catalyzes the formation of a number of reactive oxidant species. however, evidence has emerged that mpo-derived oxidants contribute to tissue damage and initiation and propagation of inflammatory diseases, particularly, cardiovascular diseases. therefore, studying the regulatory mechanisms of the enzyme activity is...

ceruloplasmin (cp) is a human plasma protein with multiple physiological functions including ferroxidase and oxidase activities. deficiency or inhibition of the enzyme may lead to some abnormalities, including iron deposition in several tissues and causes various pathological conditions in the body. direct interaction of cadmium (cd), a widespread, highly toxic environmental pollutant, with hum...

To avoid the secondary pollution that inorganic corrosion inhibitor may cause in circulating cooling water, the bio-corrosion inhibition effect of lysozyme, catalase, lipase, and laccase, as the biologic inhibitors without the above problem, and the increased bio-corrosion inhibition effect of Ca+2 and Mg+2 are studied. An enzyme with corrosion properties was selected by rotary coupon test. The...

objective(s):one strategy for the treatment of diabetes is inhibition of pancreatic α- amylase. plants contains different chemical constituents with potential for inhibition of α-amylase and hence maybe used as therapeutic. materials and methods: urtica dioica and juglans regia linn were tested for α-amylase inhibition. different concentrations of leaf aqueous extracts were incubated with enzym...