To prepare lomustine-iohexol compound liposomes, and evaluate the properties, determine the entrapment efficiency. Liposomes were prepared by reverse evaporation method; orthogonal design was used to optimize the formulation. Free drugs and liposomes were separated using protamine aggregation method and entrapment efficiency was determined by HPLC. The optimal formula was as follows: soybean ph...

A novel bio nanocomposite of Carboxymethyl Starch (CMS)-Chitosan (CS)-Montmorillonite (MMT) was developed for Curcumin delivery. To improve Curcumin entrapment into Cs-CMS-MMT, different ratios of Chitosan (Cs), Carboxymethyl Starch (CMS) and MMT were used. Particle size and Curcumin entrapment efficiency (EE) were highly affected by different formulation variables. Polysaccharide concentration...

the use of bacteriocins, mainly nisin, is one of the most significant preservation technologies in the food industry. nisin encapsulation can improve stability and homogenous distribution in food matrices. in this study, liposomes of four various lipids (lipoid s 100, lipoid s pc-3, lipoid s pc, and lipoid pc (dppc)) were prepared by dehydration-rehydration method, and compared for entrapment e...

Tuberculosis is an infectious disease caused by Mycobacterium Tuberculosis which attacks lungs and other parts of the body. Isoniazid is a hydrophilic drug that is having a first line antituberculosis drug. Entrapment Efficiency has been improved by preparing Solid Lipid Nanoparticles (SLNs). Two different variable Stearic acid and Tween 80 were used by using w/o/w double emulsion-solvent evapo...

BACKGROUND Low drug entrapment efficiency of hydrophilic drugs into poly(lactic-co-glycolic acid) (PLGA) nanoparticles is a major drawback. The objective of this work was to investigate different methods of producing PLGA nanoparticles containing minocycline, a drug suitable for periodontal infections. METHODS Different methods, such as single and double solvent evaporation emulsion, ion pair...

in this study, nystatin liposomal formulation was prepared and characterized. the physicochemical properties of formulations including vesicle size, drug entrapment stability and in vitro release were studied. the highest entrapment efficiency of nystatin into liposomes was obtained about 70% when cholesterol (cho) was added to the formulations prepared with dipalmitoylphosphatidylcholine. in a...

In this study, nystatin liposomal formulation was prepared and characterized. The physicochemical properties of formulations including vesicle size, drug entrapment stability and in vitro release were studied. The highest entrapment efficiency of nystatin into liposomes was obtained about 70% when cholesterol (CHO) was added to the formulations prepared with dipalmitoylphosphatidylcholine. In a...

objective(s): the purpose of the present study was to prepare and to evaluate a novel niosome as transdermal drug delivery system for propranolol hydrochloride and to compare the in vitro efficiency of niosome by either thin film hydration or hand shaking method. materials and methods: niosomes were prepared by thin film hydration (tfh) or hand shaking (hs) method. propranolol niosomes were pre...

The objective of this study was formulation and evaluation of mucoadhesive nanoparticles of acyclovir. Nanoparticles were prepared by one step desolvation method by using gelatin as a mucoadhesive polymer. The effects of amount of gelatin and Pluronic F-68 on particle size, polydispersity index, entrapment efficiency, loading efficiency, mucoadhesive strength were studied. Nanoparticulate formu...