Breast cancer is the most common malignancy in women worldwide. associated with a high mortality rate and health-related economic burden. patients have low 5-year life expectancy when diagnosed at advanced stages. Besides, emergence of chemoresistance breast has led to an intense search for alternative anticancer agents. One potential compounds Piperine. Several studies had found that Piperine ...

Objective: The main objective of the current research work was to formulate and evaluate Bosewellia serrata extract loaded transferosomal topical gels. To overcome drawbacks associated with oral administration in Osteoarthritis treatment. Methodology: Transferosomes were developed using different ratios Phospholipon® 90G as phospholipid, Span-60 surfactant cholesterol fluidity buffer. selected ...

there have been numerous efforts to formulate insulin into an oral dosage form. the major problems involved with the oral administration of insulin are acidic and enzymatic decomposition by the gastric medium, and poor absorption in the small intestine due to its macromolecular structure. this study attempted to test the enhancing ability of two absorption enhancers, sodium glycocholate (na-gc)...

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is responsible for the regulation genes involved in inflammation and immune responses. NF-κB may play an important role cardiovascular diseases (CVDs), atherosclerosis diabetes. Several therapeutic agents used treatment CVDs diabetes, such as pimobendan sodium–glucose cotransporter 2 inhibitors, exert anti-inflammatory effec...

the purpose of the present study was to explore the passive and electrically assisted transdermal transport of granisetron hydrochloride (gra) in solution and gel formulation through iontophoresis and also the feasibility of delivering therapeutic amounts of drug for the treatment of chemotherapy-induced nausea and vomiting. in this study, iontophoretic permeation of gra through guinea pig skin...

The objective of the existing research was formulation development and preparation microemulsion loaded emulgel in augmenting topical delivery Lornoxicam. Emulsion gel combined are recognized as Emulgels. Gelling agents Carbopol 940, 974, 980 were used to formulating Lornoxicam emulgel. drug release from determined depending on different gelling agents. Clove oil for internal phase Polyethylene...

Confocal Raman microspectroscopy (CRM) with 633- and 785-nm excitation wavelengths combined optical clearing (OC) technique was used for ex-vivo study of porcine skin in the fingerprint region. The has been performed on samples by applying a mixture glycerol distilled water glycerol, chemical penetration enhancer dimethyl sulfoxide (DMSO) during 30[Formula: see text]min 60[Formula: treatment. I...

Abstract Though long recognized as a master regulator of cell proliferation across wide range cancers, Myc has proven elusive to direct therapeutic targeting. The CDK9-containing PTEFb, complexed with either BRD4 or SEC, facilitates Myc-driven transcriptional programs and is necessary for sustaining expression itself. Advances in development clinical-grade CDK9 inhibitors creates an opportunity...

Abstract Geminiviruses are causal agents of devastating diseases in crops. have circular single-stranded (ss) DNA genomes that replicated the nucleus infected plant cell through double-stranded (ds) intermediates by replication machinery. Which host polymerase mediates geminiviral multiplication, however, has so far remained elusive. Here, we show subunits nuclear replicative polymerases ? and ...