Chantler, C., and Barratt. T. M. (1972). Archives of Disease in Childhood, 47, 613. Estimation of glomerular filtration rate from plasma clearance of 51-chromium edetic acid. The glomerular filtration rate was estimated by a single compartment analysis of the rate of fall of plasma concentration of 51-chromium edetic acid after a single intravenous injection. This slope clearance consistently o...

The addition of edetic acid (EDTA) or trypsin to the infusion during a simulated extracapsular cataract extraction on cadaver eyes facilitates the removal of lens epithelial cells from the anterior capsule. Modification of the chemical composition of infusions used during extracapsular surgery may maximise lens epithelial cell removal and hence reduce the incidence of opacification of the poste...

We have shown that the bacteriostatic and bactericidal agents edetic acid and benzaLkonium chloride present in nebuliser solutions may cause bronchoconstriction when inhaled by asthmatic patients and suggested that this may account for some of the pardoxical bronchoconstriction that occurs after inhalation ofnebulised bronchodilator aerosols. ' As antibacterial agents may be removed from nebuli...

We have shown that the bacteriostatic and bactericidal agents edetic acid and benzaLkonium chloride present in nebuliser solutions may cause bronchoconstriction when inhaled by asthmatic patients and suggested that this may account for some of the pardoxical bronchoconstriction that occurs after inhalation ofnebulised bronchodilator aerosols. ' As antibacterial agents may be removed from nebuli...

Certain strains of Staphylococcus aureus produce an enzyme capable of inactivating the bactericidal fatty acids produced in staphylococcal abscesses by esterification to various alcohols. The enzyme, called FAME (fatty acid modifying enzyme), has a pH optimum between 5.5 and 6.0 and a temperature optimum of about 40 degrees C. Enzyme activity is not affected by edetic acid or by the presence or...

In 15 children with advanced chronic renal failure, glomerular filtration rate was determined by different methods. Inulin clearance correlated well with the mean of creatinine and urea clearance, and also with 51-chromium edetic acid (EDTA) clearance measured over 24 hours. The absolute values of creatinine clearance and of 51Cr-EDTA clearance measured up to 8 hours were higher than inulin cle...