Phenotypic plasticity has been suggested to act through developmental switches, but little is known about associated molecular mechanisms. In the nematode Pristionchus pacificus, the sulfatase eud-1 was identified as part of a developmental switch controlling mouth-form plasticity governing a predatory versus bacteriovorous mouth-form decision. Here we show that mutations in the conserved histo...

The purpose of the present study was investigating kinetic and thermodynamic analysis using eudragit (EUD) polymer as controller to drug release mebendazole. nanofibers containing various proportions of EUD polymer, that were prepared with electrospinning technique.  In this study, the amount of drug mebendazole release was investigated using nanofibers containing EUD at concentrations 50, 250,...

PURPOSE Noninvasive image-guided breast brachytherapy (NIBB) is an attractive novel approach to deliver accelerated partial breast irradiation (APBI). Calculations of equivalent uniform dose (EUD) were performed to identify the appropriate APBI dose for this technique. METHODS AND MATERIALS APBI plans were developed for 15 patients: five with three-dimensional conformal APBI (3D-CRT), five wi...

We apply the concept of equivalent uniform dose (EUD) to our data set of model distributions and intensity modulated radiotherapy (IMRT) treatment plans as a method for analyzing large dose inhomogeneities within the tumor volume. For large dose nonuniformities, we find that the linerar-quadratic based EUD model is sensitive to the linear-quadratic model parameters, alpha and beta, making it ne...

This paper presents requirements elicitation study for a EUD tool for composing service-based applications. WIRE aims at enabling EUD by harvesting and recommending community composition knowledge (the wisdom), thus facilitating knowledge transfer from developers to end-users. The idea was evaluated with 10 contextual interviews to accountants, eliciting a rich set of information, which can lea...

BACKGROUND The production of protein drugs has recently increased due to advances in biotechnology, but their clinical use is generally limited to parenteral administration due to low absorption in non-parenteral administration. Therefore, non-parenteral delivery systems allowing sufficient absorption draw much attention. METHODS Microparticles (MP) were prepared using chitosan-4-thio-butylam...

Developmental plasticity has been suggested to facilitate phenotypic diversity, but the molecular mechanisms underlying this relationship are little understood. We analyzed a feeding dimorphism in Pristionchus nematodes whereby one of two alternative adult mouth forms is executed after an irreversible developmental decision. By integrating developmental genetics with functional tests in phenoty...

Several recent approaches to EUD increasingly recognize an active role of the users in the construction of the tools supporting their daily practices. However, there is still a lack of a general framework that could play a role in the comparison of existing proposals and in the development of new EUD solutions. The paper proposes a conceptual framework and a related architecture, called Logic o...

The purpose of this study was to synthesize duloxetine (DLX)- loaded Eudragit-Chitosan (Eud-CHT) nanoparticles enclosed in an oral gelatin capsule and evaluate the potential transport DLX blood-brain barrier (BBB)for improved neuro-availability. utilization Eudragit® with chitosan offers a pH-dependent controlled drug release. physicochemical properties formulated DLX-loaded Eud-CHT nanosystem ...