BACKGROUND Electrospray ionization mass spectrometry (ESIMS) has been successfully applied to the identification of hemoglobin (Hb) variants and the presence of glucose adducts (mass difference of 162 Da) on the separate Hb alpha and beta chains. To establish the potential of ESIMS as a routine and/or a reference method for the quantification of glycohemoglobin (HbA1c), we carried out a detaile...

Metabolites that incorporate elements other than carbon, nitrogen, hydrogen and oxygen can be selectively detected by inductively coupled mass spectrometry (ICPMS). When used in parallel with chromatographic separations conventional electrospray ionization (ESIMS), ICPMS allows the analyst to quickly find, characterize identify target metabolites carry nutrient (P, S, trace metals; “nutrient me...

The Cytochrome P450 CYP1A2 is a central enzyme in the metabolism of drugs and xenobiotics. overall activity this influenced by complex array biochemical, dietary, genetic factors. One simplest ways to probe output measure ratio between concentration precursor product its activity. With growing interest Paraxanthine/Caffeine ratio, need arises develop improved analytical methods specifically opt...

voltage source inverters. An example of bearing fluting is shown and system models presented and discussed. The construction details and test results for several ESIMs are presented. Experimental results show the ESIM solves the electrostatically induced rotor shaft voltage and bearing problem without degrading the electromagnetic performance of the motor.

Ten myrsinol diterpenes, euphorbiaproliferins A-J (1-10), along with nine known analogues (11-19) were isolated from the roots of Euphorbia prolifera. Their structures were elucidated by spectroscopic data analysis (IR, ESIMS, HRESIMS, 1D and 2D NMR), and the structure of 1 was confirmed by X-ray crystallography. The diterpenes showed neuroprotective effects against MPP+-induced neuronal cell d...

Investigation of an extract from the marine cyanobacterium Lyngbya semiplena, collected in Tumon Bay, Guam, led to the identification of three new cyclodepsipeptides, lyngbyastatins 8-10 (1-3). The structures of 1-3 were determined by NMR, MS, ESIMS fragmentation and chemical degradation. Compounds 1-3 are closely related to lyngbyastatins 4-7. Like the latter compounds, we found 1-3 to inhibit...

Three new norzoanthamine-type alkaloids, named 2-hydroxy-11-ketonorzoan thamide B (1), norzoanthamide B (2) and 15-hydroxynorzoanthamine (3), were isolated from Zoanthus sp. specimens collected at the Canary Islands. Their structures were determined by interpretation of NMR and HR-ESIMS data. Relative configurations of their chiral centers were proposed on the basis of ROESY spectra and by comp...

Submit Manuscript | http://medcraveonline.com Abbreviations: PLGA: Poly Lactic-Co-Glycolic Acid; PEG: Polyethylene Glycol; FDA: Food and Drug Administration; AlgPLGANP: Alginate-PLGA Nanoparticle; PDI: Polydispersity Index; TRF: Tocotrienol Rich Fraction; FA: Folic Acid; α: Alpha; ZP: Zeta Potential; SEM: Scanning Electron Microscopy; PXRD: Powder X ray Diffraction; DSC: Differential Scanning C...