The possibility to reprogram somatic human cells will greatly and deeply change genetic approach and allow the development of new tools to study genetics diseases. Indeed, our ability to study human genetic diseases suffers from the lack of valid in vitro models. The latter should (i) be originating from human primary cells, (ii) be able to self-renew for a long time and (iii) be able to differ...

There is an increased awareness of the roles that enterprise architecture (EA) and enterprise systems (ES) play in today’s organizations. EA and ES usage maturity models are used to assess how well companies are capable of deploying these two concepts while striving to achieve strategic corporate goals. The existence of various architecture and ES usage models raises questions about how they bo...

In models of plant volatile isoprenoid emissions, the instantaneous compound emission rate typically scales with the plant’s emission potential under specified environmental conditions, also called as the emission factor, ES. In the most widely employed plant isoprenoid emission models, the algorithms developed by Guenther and colleagues (1991, 1993), instantaneous variation of the steady-state...

Embryonic stem (ES) cell-based gene manipulation is an effective method for the generation of mutant animal models in mice and rats. Availability of germline-competent ES cell lines from inbred rat strains would allow for creation of new genetically modified models in the desired genetic background. Fischer344 (F344) males carrying an enhanced green fluorescence protein (EGFP) transgene were us...

Detailed finite element side impact dummy models of the USSID and EUROSID have been developed in cooperation with the German Association for Automotive Research (FAT) during the last 5 years. Both models are validated using tests at material and component levels as well as fully assembled models. The development of the LS-DYNA dummy models has been performed by the authors. Both models are used...