AIMS Ergot-derived dopamine agonists (EDDA) induce fibrotic heart valve disease. We aimed to investigate whether EDDA treatment also affects left ventricular (LV) function. METHODS AND RESULTS Myocardial function was evaluated in 110 Parkinson patients [mean age (63.4 +/- 9.0 years)] treated for at least 6 months with either EDDA (n = 71) or non-EDDA (n = 39). LV ejection fraction did not dif...

The first derivative of carboxypeptidase A, cobalt(III)(ethylenediamine-N,N’-diacetato)(arsanilazotyrosinato 248 (Co(III)(EDDA)(AA-CPA-Zn)), in which only the active site residue tyrosine 248 is blocked, has been shown to be completely peptidase-inactive while retaining esterase activity. Peptides are excellent inhibitors of esterase activity showing Ki values somewhat below the corresponding K...

OBJECTIVE The aim of this study was to assess the diagnostic efficiency of (99m)Tc-EDDA/HYNIC-Octreotate in comparison with (111)Inpentetrotide scintigraphy in the detection of neuroendocrine tumors. This study also evaluates the impact of SPECT-CT hybrid imaging on somatostatin receptor scintigraphy (SRS) interpretation and clinical management of these tumors. METHODS Fourteen patients were ...

The first derivative of carboxypeptidase A, cobalt(III)(ethylenediamine-N,N’-diacetato)(arsanilazotyrosinato 248 (Co(III)(EDDA)(AA-CPA-Zn)), in which only the active site residue tyrosine 248 is blocked, has been shown to be completely peptidase-inactive while retaining esterase activity. Peptides are excellent inhibitors of esterase activity showing Ki values somewhat below the corresponding K...

PURPOSE The aim of our study was to assess diagnostic accuracy of Tc-99m depreotide and Tc-99m-EDDA/HYNIC-TOC scintigraphy for evaluation of pulmonary lesions that appeared ambiguous on computed tomography (CT). MATERIAL AND METHODS Forty-nine consecutive patients (37 men and 12 women; mean age, 60 ± 11 years) with 60 pulmonary lesions on chest radiography and CT were referred for nuclear ima...

BACKGROUND Human T lymphocytes infiltrating tissues in autoimmune diseases are known to express somatostatin receptors amongst other activation markers. In this study, we evaluated whether somatostatin receptor scintigraphy (SRS) using a radiolabelled somatostatin analogue ((99m)Tc-EDDA/tricine-HYNIC-tyr(3)-octreotide ((99m)Tc-EDDA/HYNIC-TOC)) is able to detect the presence of immune-mediated p...

The binding selectivity of the M(phen)(edda) (M=Cu, Co, Ni, Zn; phen=1,10-phenanthroline, edda=ethylenediaminediacetic acid) complexes towards ds(CG)(6), ds(AT)(6) and ds(CGCGAATTCGCG) B-form oligonucleotide duplexes were studied by CD spectroscopy and molecular modeling. The binding mode is intercalation and there is selectivity towards AT-sequence and stacking preference for A/A parallel or d...

Many researchers and organizations are interested in creating a mechanism capable of automatically predicting software defects. In the last years, machine learning techniques have been used in several researches with this goal. Many recent researches use data originated from NASA (National Aeronautics and Space Administration) IV&V (Independent Verification & Validation) Facility Metrics Data P...

SP94 (SFSIIHTPILPL), a novel peptide, has shown specific binding to hepatocellular carcinoma (HCC) cells. We aimed to investigate the capability of SP94 as a targeting probe for HCC imaging and therapy following labeling with technetium-99m ((99m)Tc) and rhenium-188 ((188)Re). HYNIC-SP94 was prepared by solid phase synthesis and then labeled with (99m)Tc. Cell competitive binding, internalizati...