BACKGROUND Focal acantholytic dyskeratosis has been described as an incidental finding and as a clinically distinct lesion. In both situations, a dimorphic histologic pattern is observed: acantholysis and dyskeratosis. Solitary, non-genital lesions displaying such pathology have been difficult to classify. Clinical and pathological characteristics of acantholytic dyskeratotic acanthomas are des...

We report a case of a 35-year-old female with a persistent pruritic acantholytic and dyskeratotic eruption on the chest and vulva. The light and electron microscopic studies showed suprabasal epidermal clefting with acantholysis and dyskeratotic cells. We suggest that the most appropriate term for this case is that of benign persistent papular acantholytic and dyskeratotic eruption.

Patients with keratotic lesions distributed in a unilateral, linear, zosteriform or localized pattern and revealing histopathologic features of dyskeratotic acantholysis have been reported previously. There is some controversy in the appropriate nosologic classification of this entity. Some authors consider it as a localized form of Darier’s disease while others place it as a variant of e...

Abstract A 35-year-old woman presented with a 4-year history of persistent pruritic rash affecting her upper and lower limbs, concerning to the patient for cosmetic reasons. She denied any precipitating factors reported no improvement use topical clobetasol propionate. Notably, mother had similar rash, which also developed in 30s continued progress over time. Physical examination revealed bilat...

Grover's disease is a benign condition of unknown origin characterized clinically by an erythematous papulovesicular eruption and histopathologically by intraepidermal clefting and four different patterns of acantholysis: Darier-like, pemphigus-like, spongiotic, and Hailey-Hailey-like. A case of a 54-year-old female affected by Grover's disease and showing a Darier-like histopathological patter...

Darier's disease is a rare genodermatosis caused by a defect in ATP2A2 gene located on chromosome 12q23-23 (1). This somatic mutation rarely occurs in the postzygotic phase of embryogenesis, leading to cutaneous mosaicism for the disease. The mosaic form of Darier's disease is also called linear Darier's disease and clinically presents with linear, zosteri-form or localized patterns located on ...

Dear Editor, Reticulate pigmentary disorders (RPD) is a term used to classify a spectrum of several acquired and congenital disorders. Different clinical features can be present, including a reticular pattern and a freckle-like pattern with hyperor hypo-pigmented macules (1). Dowling-Degos disease (DDD), an autosomal dominant genodermatosis, is the main type of RPD (2). Clinically, DDD presents...

Rodin et al. first reported a rare inherited condition in 1967, called as familial dyskeratotic comedones (FDC) with autosomal dominant mode of inheritance and clinically characterized by symmetrical development of cosmetically disfiguring, progressive but asymptomatic, numerous, discrete, disseminated, hyperkeratotic papules and comedones on trunk, arms and face, appearing around puberty [1]. ...