background and objective: since the advent of mammography screening, ductal carcinoma in situ (dcis) of the breast has been diagnosed increasingly. in contrast to the situation in invasive breast carcinoma, there are only a few reports on androgen receptor (ar) status in dcis and few reports on estrogen (er) and progesterone (pr) receptors. materials and methods: ar expression was examined in 5...

malignant papillary neoplasms of the breast comprise a number of microscopically distinct lesions, where apocrine metaplasia is commonly found in papillomas compared to other papillary lesions including papillary carcinomas. however, association of apocrine metaplasia in papilloma with ductal carcinoma in situ (dcis) is not very well defined. the lesions with apocrine metaplasia are not only di...

juvenile fibroadenoma is an uncommon histologic variant of fibroadenoma that frequently shows a remarkable and rapid growth. the development of a carcinoma within a fibroadenoma, either in situ or invasive, is a rare condition. we encountered a 36-year-old woman with a palpable mass in the right breast. the radiologic findings were indicative of a fibroadenoma in the breast. sonographic guided ...

the focus of this study was to determine if early detection of mutant p53 accumulation may be an early indicator of tumor aggressiveness and transformation to invasive breast cancer. for this purpose, the p53 content of 100 human breast biopsies classified as ductal carcinoma (dcis), was evaluated by immunohistochemical method. all specimens were microscopically classified into histologic types...

Background and Objective: Since the advent of mammography screening, ductal carcinoma in situ (DCIS) of the breast has been diagnosed increasingly. In contrast to the situation in invasive breast carcinoma, there are only a few reports on androgen receptor (AR) status in DCIS and few reports on estrogen ...

OBJECTIVE To determine the frequency of the immunohistochemical profiles of a series of high-grade ductal carcinoma in situ of the breast. METHODS One hundred and twenty-one cases of high-grade ductal carcinoma in situ, pure or associated with invasive mammary carcinoma, were identified from 2003 to 2008 and examined with immunohistochemistry for estrogen receptor, human epidermal growth fact...

The transition from ductal carcinoma in situ to invasive ductal carcinoma is a key event in breast cancer progression that is still not well understood. To discover the microRNAs regulating this critical transition, we used 80 biopsies from invasive ductal carcinoma, 8 from ductal carcinoma in situ, and 6 from normal breast. We selected them from a recently published deep-sequencing dataset [Fa...

Skin-sparing mastectomy with immediate breast reconstruction can provide an excellent cosmetic result. Despite its increasing popularity, few studies have assessed the risk of recurrence when the procedure is used for the treatment of ductal carcinoma in situ. To evaluate the oncologic safety of skin-sparing mastectomy used for the treatment of ductal carcinoma in situ, the recurrence rate was ...