this study aims to design some dual-target anticancer candidates, capable to act as an alkylating agent as well as a thymidylate synthase (ts) inhibitor. the designed scaffold is a combination of nucleobase, amino acid and aziridine structures. the candidates are docked into ts and three dna double strand structures and evaluated based on their binding interaction energies and ligand efficienci...

This study aims to design some dual-target anticancer candidates, capable to act as an alkylating agent as well as a thymidylate synthase (TS) inhibitor. The designed scaffold is a combination of nucleobase, amino acid and aziridine structures. The candidates are docked into TS and three DNA double strand structures and evaluated based on their binding interaction energies and ligand efficienci...

This study examined the effect of working memory training on vocabulary recall and retention ofIranian EFL learners using dual N-back task technique. To this end, 50 EFL learners at IslamicAzad University of Shoushtar were randomly assigned to the experimental (n = 25) and control (n= 25) groups. Before the treatment, a vocabulary test was administered to the participants to assessthe participa...

Steel Plate Shear Wall (SPSW) is an emerging seismic load-resistant system that, compared to other systems, enjoys the advantages of stable ductile behavior, fewer detailing requirements, rapid constructability, and economy. American seismic provisions decree that a SPSW should be designed as a moment frame with a web infill plate. Specifically, in case of buildings taller than 160 ft, it decre...

Simultaneous search for two targets has been shown to be slower and less accurate than independent searches for the same two targets. Recent research suggests this 'dual-target cost' may be attributable to a limit in the number of target-templates than can guide search at any one time. The current study investigated this possibility by comparing behavioural responses during single- and dual-tar...